848188-36-3Relevant academic research and scientific papers
A Highly Efficient Heterogeneous Copper-Catalyzed Oxidative Cyclization of Benzylamines and 1,3-Dicarbonyl Compounds to Give Trisubstituted Oxazoles
Cai, Mingzhong,Tuo, Yuxin,Wei, Li,You, Shengyong
, p. 3091 - 3100 (2019/08/07)
The heterogeneous copper-catalyzed cascade oxidative cyclization between benzylamines and 1,3-dicarbonyl compounds was achieved by using the 3-(2-aminoethylamino)propyl-functionalized MCM-41-immobilized copper(II) complex [MCM-41-2N-Cu(OAc) 2 ] as catalyst and t -BuOOH (TBHP) as oxidant, with iodine as additive, under mild conditions, yielding a wide variety of 2,4,5-trisubstituted oxazoles in mostly good to excellent yields. This heterogeneous copper catalyst can be facilely prepared via a simple two-step procedure from readily available and inexpensive reagents and exhibits a slightly higher activity than Cu(OAc) 2. MCM-41-2N-Cu(OAc) 2 is also easy to recover and can be recycled up to eight times with almost consistent activity. The reaction is the first example of heterogeneous copper-catalyzed intermolecular cyclization for the construction of polysubstituted oxazoles.
Structure-activity relationship of new anti-tuberculosis agents derived from oxazoline and oxazole benzyl esters
Moraski, Garrett C.,Chang, Mayland,Villegas-Estrada, Adriel,Franzblau, Scott G.,M?llmann, Ute,Miller, Marvin J.
experimental part, p. 1703 - 1716 (2010/06/19)
During the syntheses and studies of natural iron chelators (mycobactins), we serendipitously discovered that a simple, small molecule, oxazoline-containing intermediate 3 displayed surprising anti-tuberculosis activity (MIC of 7.7?μM, average). Herein we
Syntheses and biological activity of amamistatin B and analogs
Fennell, Kelley A.,Moellmann, Ute,Miller, Marvin J.
, p. 1018 - 1024 (2008/09/18)
(Chemical Equation Presented) Amamistatins A and B, natural products isolated from a strain of Nocardia, showed growth inhibition against three human tumor cell lines (IC50 0.24-0.56 μM). Structurally related mycobactins affect the growth of bo
Syntheses of amamistatin fragments and determination of their HDAC and antitumor activity
Fennell, Kelley A.,Miller, Marvin J.
, p. 1683 - 1685 (2008/02/02)
Amamistatins A and B are natural products found to have anti-proliferative effects against MCF-7, A549, and MKN45 human tumor cell lines (IC50 0.24-0.56 μM). It was proposed that their activity was due to histone deacetylase (HDAC) inhibition m
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors
Razavi, Hossein,Powers, Evan T.,Purkey, Hans E.,Adamski-Werner, Sara L.,Chiang, Kyle P.,Dendle, Maria T. A.,Kelly, Jeffery W.
, p. 1075 - 1078 (2007/10/03)
Ten oxazoles bearing a C(4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C(2) position of the oxazole ring reveals that a 3,5-dichlorophenyl substituent significantly reduced amy
