848302-18-1Relevant academic research and scientific papers
Alpha-hydroxy-ketone compound synthesis method
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Paragraph 0064; 0065; 0066; 0067; 0068, (2017/07/19)
The invention discloses an alpha-hydroxy-ketone compound synthesis method. In the prior art, a noble metal complex, an organophosphorus compound or an iodine elementary substance is always used as a catalyst, the price is high and the recycle cost is higher; used alkali is organic alkali with a complex structure or unusual inorganic alkali such as cesium carbonate which is high in price; a used solvent is always selected from aprotic organic solvents, the post-treatment is complex, and industrialized application is difficult to realize. According to the alpha-hydroxy-ketone compound synthesis method provided by the invention, common inorganic sulfocompounds with low price are adopted as the catalyst, under the alkali and aerobic condition, a carbonyl compound is catalyzed to react to obtain the alpha-hydroxy-ketone compound. The invention has the advantages that the used raw materials are easy to obtain, the price is low, the yield is high, the product purity is high, the waste amount is less and easy to treat, and industrialization is easy to realize.
Diastereoselective amidoalkylation of (3S,7aR)-6-benzyl-7-hydroxy-3- phenyltetrahydro-5H-imidazo[1,5-c][1,3]thiazol-5-one: A short and highly efficient synthesis of (+)-biotin
Chavan, Subhash P.,Chittiboyina, Amar G.,Ravindranathan,Kamat, Subhash K.,Kalkote, Uttam R.
, p. 1901 - 1903 (2007/10/03)
(Chemical Equation Presented) A short and highly efficient synthesis of (+)-biotin in 10 steps with 20% overall yield has been achieved from L-cysteine involving amidoalkylation of hydroxy imidazothiazolone 4 via an acyliminium ion intermediate to furnish C-7-substituted imidazothiazolones 5b as the key step.
