84857-14-7Relevant academic research and scientific papers
Synthesis of Benzazolyl Pyrimidines Under Ultrasonication and Their Antimicrobial Activity
Kayathi, Narendra Babu,Sowmya, Donthamsetty V.,Adivireddy, Padmaja,Venkatapuram, Padmavathi
, p. 1024 - 1032 (2018)
(1) The benzoxazolyl/benzothiazolyl/benzimidazolyl pyrimidines were prepared under ultrasonication in the presence of pyridine/dimethylaminopyridine and triethylamine. (2) Better yields were recorded in 4-(N,N-dimethylamino)pyridine and Et3N. (3) The presence of electron withdrawing chloro, bromo, and nitro substituents enhanced antimicrobial activity (13c, 13e, 14e: minimum inhibitory concentration?=?6.25?μg/well against Bacillus subtilis; 13e, 14e: minimum inhibitory concentration?=?6.25?μg/well against Aspergillus niger).
A green approach for the synthesis of benzazolyl pyrimidinyl carbamothioates under ultrasonication and their antimicrobial activity
Kayathi, Narendra Babu,Panga, Siva Sankar,Adivireddy, Padmaja,Venkatapuram, Padmavathi
, p. 2931 - 2943 (2021/07/26)
A library of benzazolyl pyrimidinyl carbamothioates were prepared by the reaction of benzazolyl carbonothioates with pyrimidinyl-2-amine in the presence of an ionic liquid- 1-butyl-3-methylimidazolium hydroxide ([bmim]OH) under ultrasonication at a frequency of 35?kHz and tested for antimicrobial activity. Chloro- and nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates displayed prominent antibacterial activity against Bacillus subtilis, while nitro-substituted benzothiazolyl/benzimidazolyl pyrimidinyl carbamothioates showed excellent antifungal activity against Aspergilus niger. Graphic abstract: [Figure not available: see fulltext.].
Iron Catalyzed Synthesis of Pyrimidines Under Air
Mondal, Rakesh,Sinha, Suman,Das, Siuli,Chakraborty, Gargi,Paul, Nanda D.
supporting information, p. 594 - 600 (2019/12/15)
Herein we report an iron-catalyzed multicomponent dehydrogenative functionalization of alcohols to pyrimidines under atmospheric conditions. Using a well-defined Fe(II)-complex featuring redox noninnocent 2-phenylazo-(1,10-phenanthroline) ligand, as a cat
Influence of the C-5 substitution in polysubstituted pyrimidines on inhibition of prostaglandin E2 production
Kolman, Viktor,Kal?ic, Filip,Jansa, Petr,Zídek, Zdeněk,Janeba, Zlatko
, p. 295 - 301 (2018/07/14)
As a part of a broader structure-activity relationship study of substituted 2-aminopyrimidines, the influence of the C-5 substitution on inhibition of prostaglandin E2 (PGE2) production was studied. Thirty compounds were prepared sta
Synthesis and Antimicrobial Activity of Azolyl Pyrimidines
Butta, Ragavendra,Donthamsetty V, Sowmya,Adivireddy, Padmaja,Venkatapuram, Padmavathi
, p. 524 - 530 (2017/02/03)
A new class of azolyl pyrimidines linked by diamino sulfone moiety was prepared and studied their antimicrobial activity. Chloro-substituted and nitro-substituted thiazolyl pyrimidines (9c and 9e) showed excellent antibacterial activity against Bacillus subtilis, while imidazolyl pyrimidines (10c and 10e) exhibited promising antifungal activity against Aspergillus niger.
Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists
Yaziji, Vicente,Rodríguez, David,Gutiérrez-De-Terán, Hugo,Coelho, Alberto,Caama?o, Olga,García-Mera, Xerardo,Brea, José,Loza, María Isabel,Cadavid, María Isabel,Sotelo, Eddy
supporting information; experimental part, p. 457 - 471 (2011/04/15)
Two regioisomeric series of diaryl 2- or 4-amidopyrimidines have been synthesized and their adenosine receptor affinities were determined in radioligand binding assays at the four human adenosine receptors (hARs). Some of the ligands prepared herein exhib
Reaction of α,β-Unsaturated Ketones with Guanidine. Substituent Effects on the Protonation Constants of 2-Amino-4,6-diarylpyrimidines
Al-Hajjar, Farouk H.,Sabri, Salim S.
, p. 1087 - 1092 (2007/10/02)
1.3-Diaryl-2-propen-1-ones, I, reacted with guanidine hydrochloride (II) in the presence of 3 moles of sodium hydroxide to give the corresponding 2-amino-4,6-diarylpyrimidines, III.The structure and configuration of the products are based on chemical and
