848773-52-4Relevant academic research and scientific papers
Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13)
Kim, Soong-Hoon,Pudzianowski, Andrew T.,Leavitt, Kenneth J.,Barbosa, Joseph,McDonnell, Patricia A.,Metzler, William J.,Rankin, Bruce M.,Liu, Richard,Vaccaro, Wayne,Pitts, William
, p. 1101 - 1106 (2007/10/03)
Computer aided drug design led to a new class of spiro-barbiturates (e.g., 4a, MMP-13 Ki = 4.7 nM) that are potent inhibitors of MMP-13.
