84892-43-3Relevant academic research and scientific papers
Cobalt-Catalyzed Desymmetric Isomerization of Exocyclic Olefins
Lan, Yu,Liu, Qiang,Liu, Shihan,Liu, Xufang,Rong, Xianle
, p. 20633 - 20639 (2021/12/17)
Chiral cyclic olefins, 1-methylcyclohexenes, are versatile building blocks for the synthesis of pharmaceuticals and natural products. Despite the prevalence of these structural motifs, the development of efficient synthetic methods remains an unmet challenge. Herein we report a novel desymmetric isomerization of exocyclic olefins using a series of newly designed chiral cobalt catalysts, which enables a straightforward construction of chiral 1-methylcyclohexenes with diversified functionalities. The synthetic utility of this methodology is highlighted by a concise and enantioselective synthesis of a natural product, β-bisabolene. The versatility of the reaction products is further demonstrated by multifarious derivatizations.
NOVEL 5 or 8-SUBSTITUTED IMIDAZO [1, 5-a] PYRIDINES AS SELECTIVE INHIBITORS OF INDOLEAMINE AND/OR TRYPTOPHANE 2, 3-DIOXYGENASES
-
, (2018/04/20)
Disclosed herein are 5 or 8-substituted imidazo [1, 5-a] pyridines and pharmaceutical compositions comprising at least one such 5 or 8-substituted imidazo [1, 5-a] pyridines, processes for the preparation thereof, and the use thereof in therapy. Disclosed herein are certain 5 or 8-substituted imidazo [1, 5-a] pyridines that can be useful for inhibiting indoleamine 2, 3-dioxygenase and/or tryptophane 2, 3-dioxygenase and for treating diseases or disorders mediated thereby.
A Search for Photoresolvable Mesogens: Synthesis and Properties of a Series of Liquid Crystalline, Axially Chiral 1-Benzylidene-4-phenyl>cyclohexanes
Zhang, Yifan,Schuster, Gary B.
, p. 1855 - 1862 (2007/10/02)
A series of axially chiral 1-benzylidene-4-ethynyl>phenyl>cyclohexanes was prepared in racemic form and as optically active mixtures by application of the Hanessian olefination reaction.These compounds have two spectrally overlapping g
Liquid-crystalline biphenyl or terphenyl derivatives
-
, (2008/06/13)
New liquid crystal (l. c.) compounds having a positive dielectric anisotropy, 4"-(β-alkyloxyethyl)-4-cyanobiphenyls and 4'-(β-alkyloxyethyl)-4-cyanoterphenyls expressed by the general formula STR1 wherein R represents an alkyl group of 1?9C and n is 2 or 3; a process for preparing the same; and l.c. compositions containing at least one of the same, are provided. When the compounds are added to a l.c. having a nearly zero or negative anisotropy, a l.c. composition having a positive dielectric anisotropy can be obtained. The compounds have a greater optical anisotropy and a superior compatibility with other l.c. compounds.
