848926-12-5

Basic information

• Product Name: (R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol
• Synonyms: (R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol
• CAS NO: 848926-12-5
• Molecular Weight: 194.129
• Mol File: 848926-12-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: (R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol(848926-12-5)
• EPA Substance Registry System: (R)-2,2,2-trifluoro-1-(4'-fluorophenyl)ethanol(848926-12-5)

Safety Data

• Hazardous Substances Data: 848926-12-5(Hazardous Substances Data)

Upstream product

• 655-32-3 2,2,2-trifluoro-1-(4-fluorophenyl)ethanone 
• 557-20-0 diethylzinc 
• 459-57-4 4-fluorobenzaldehyde 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 17556-41-1 2,2,2-trifluoro-1-(4-fluorophenyl)ethanol 
• 97-72-3 2-Methylpropionic anhydride 

Downstream Products

• 880762-43-6 trifluoromethanesulfonic acid (R)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl ester 

Relevant articles and documents

Chemo- and Enantioselective Addition and β-Hydrogen Transfer Reduction of Carbonyl Compounds with Diethylzinc Reagent in One Pot Catalyzed by a Single Chiral Organometallic Catalyst

Using a single chiral phosphoramide-Zn(II) complex as the catalyst, the asymmetric β-H transfer reduction of aromatic α-trifluoromethyl ketones and enantioselective addition of aromatic aldehydes with Et2Zn in one pot were successfully realized, affording the corresponding additive products of secondary alcohols in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee) and the reduction products of α-trifluoromethyl alcohols in good to excellent yields with up to 77% ee.

Development of an Immobilized Ketoreductase for Enzymatic (R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethanol Production

The development of an immobilized ketoreductase via covalent binding on resin EC-HFA has demonstrated that it is highly active and stable in organic solvents and can be recycled and reused many times in both batch mode and flow reactor mode. (R)-1-(3,5-Bi

Asymmetric hydrosilylation of ketones catalyzed by complexes formed from trans-diaminocyclohexane-based diamines and diethylzinc

Chiral acyclic and macrocyclic amines derived from trans-1,2- diaminocyclohexane in complexes with diethylzinc efficiently catalyze asymmetric hydrosilylation of aryl-alkyl and aryl-aryl ketones with enantiomeric excess of the product up to 86 %. A trianglamine ligand with a cyclic structure or the presence of an additional coordinating group increases the enantioselectivity of the reaction, in comparison with catalysis by a simple acyclic N,N′-dibenzyl-1,2-diaminocyclohexane ligand. In addition, the effect of the asymmetric activation of the catalyst by a variety of alcohols and diols is studied.