84907-57-3

Upstream product

• 18282-51-4 4-iodo-benzyl alcohol 
• 75-20-7 calcium carbide 
• 873-75-6 4-bromobenzenemethanol 
• 275386-60-2 4-(hydroxymethyl)-1-(trimethylsilylethynyl)benzene 
• 10602-04-7 (4-ethynylphenyl)methanol 
• 74-86-2 acetylene 
• 2789-89-1 1,2-bis(4-bromophenyl)acetylene 
• 84907-55-1 tolan-4,4'-dicarbaldehyde 

Downstream Products

• 5140-98-7 4,4′-bis(bromomethyl)tolan 

Relevant academic research and scientific papers

Twisting of Alkynes towards a Carbon Double Helix

The carbon allotrope exhibiting only one-dimensional sp-hybridized carbon atoms is called carbyne. However, its existence is very controversial. Studies on model compounds for carbyne revealed that many oligoalkynes show not a straight, but a bent structu

ORGANIC COMPOUNDS TO TREAT HEPATITIS B VIRUS

The disclosure relates to compositions comprising a HBV RNAi agent. In some embodiments, the HBV RNAi agent comprises a sense and an anti-sense strand, each strand being an 18-mer and the strands together forming a blunt-ended duplex, wherein the 3′ end of at least one strand terminates in a phosphate or modified internucleoside linker and further comprises, in 5′ to 3′ order: a spacer; a second phosphate or modified internucleoside linker; and a 3′ end cap. In some embodiments, the 3′ end of both the sense and anti-sense strand further comprise, in 5′ to 3′ order: a spacer; a second phosphate or modified internucleoside linker; and a 3′ end cap. The two strands can have the same or different spacers, phosphates or modified internucleoside linkers, and/or 3′ end caps. The strands can be ribonucleotides, or, optionally, one or more nucleotide can be modified or substituted. Optionally, at least one nucleotide comprises a modified internucleoside linker. Optionally, the RNAi agent can be modified on one or both 5′ end. Optionally, the sense strand can comprise a 5′ end cap which reduces the amount of the RNA interference mediated by this strand. Optionally, the RNAi agent is attached to a ligand. This format can be used to devise RNAi agents to a variety of different targets and sequences. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference. The disclosure also pertains to methods of treating, ameliorating and preventing HBV in a patient involving the step of administering to the patient a therapeutic amount of a HBV RNAi agent.

3'END CAPS FOR RNAi AGENTS FOR USE IN RNA INTERFERENCE

The disclosure relates to novel compounds and compositions comprising a RNAi agent comprising a novel compound as a 3' end cap. The disclosure also relates to processes for making such compositions, and methods and uses of such compositions, e.g., to mediate RNA interference.

Calcium carbide as a cost-effective starting material for symmetrical diarylethynes via Pd-catalyzed coupling reaction

A convenient and cost-effective synthetic method for symmetrical diarylethynes from inexpensive calcium carbide and aryl iodide has been developed. The reaction not only proceeds with high yield and selectivity but also tolerates a wide range of functional groups. Application of this reaction has enabled the synthesis of highly functionalized oligo (phenyleneethynylenes) to be accomplished.

6>Paracyclophanes - Large Ring Compounds with Extended ?-Systems

Two 6>paracyclophanes with unsaturated bridges, containing perimeters with 36 ?-electrons, have been prepared by fourfold Wittig reactions.Attempts to prepare cyclophanes with even larger ?-systems are reported.The reversible two-electron red