849697-81-0Relevant academic research and scientific papers
Discovery of orally efficacious melanin-concentrating hormone receptor-1 antagonists as antiobesity agents. Synthesis, SAR, and biological evaluation of bicyclo[3.1.0]hexyl ureas
McBriar, Mark D.,Guzik, Henry,Shapiro, Sherry,Paruchova, Jaroslava,Xu, Ruo,Palani, Anandan,Clader, John W.,Cox, Kathleen,Greenlee, William J.,Hawes, Brian E.,Kowalski, Timothy J.,O'Neill, Kim,Spar, Brian D.,Weig, Blair,Weston, Daniel J.,Farley, Constance,Cook, John
, p. 2294 - 2310 (2007/10/03)
Melanin-concentrating hormone (MCH) is a cyclic, nonadecapeptide expressed in the CNS of all vertebrates that regulates feeding behavior and energy homeostasis via interaction with the central melanocortin system. Regulation of this interaction results in
Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: Orally efficacious antiobesity therapeutics
McBriar, Mark D.,Guzik, Henry,Xu, Ruo,Paruchova, Jaroslava,Li, Shengjian,Palani, Anandan,Clader, John W.,Greenlee, William J.,Hawes, Brian E.,Kowalski, Timothy J.,O'Neill, Kim,Spar, Brian,Weig, Blair
, p. 2274 - 2277 (2007/10/03)
Melanin concentrating hormone (MCH) is involved in regulation of food intake and energy homeostasis. Antagonists of the MCH receptor are expected to affect food intake and weight gain, making MCH-R1 an attractive target for obesity treatment. Herein, we r
