850089-95-1

Upstream product

• 582-24-1 1-phenyl-2-hydroxyethanone 
• 1005-02-3 2-pyridinecarbohydrazonamide 
• 1074-12-0 phenylglyoxal hydrate 
• 41939-97-3 hydrazonophenylacetaldehyde oxime 
• 1121-60-4 pyridine-2-carbaldehyde 
• 517876-02-7 6-phenyl-3-(pyridin-2-yl)-1,2,4-triazin-4(3H)-ol 
• 1452-63-7 picolinic acid hydrazide 
• 70-11-1 α-bromoacetophenone 
• 532-54-7 E-isonitrosoacetophenone 
• 98-86-2 acetophenone 

Downstream Products

• 1202524-90-0 2-(6-phenyl-3-(pyridin-2-yl)-2,5-dihydro-1,2,4-triazin-5-yl)cyclobutanone 
• 1204187-21-2 (R,S)-[6-phenyl-3-(2-pyridyl)-2,5-dihydro-2(H)-1,2,4-triazin-5-yl]ferrocene 
• 1415648-16-6 3-phenyl-2-[6-phenyl-3-(2-pyridyl)-1,2,4-triazin-5-yl]-1,4-diazaspiro[4.5]decane-1,3-diene 
• 1429433-72-6 4-phenyl-1-(2-pyridyl)benzo[h]isoquinoline 

Relevant academic research and scientific papers

Promising Antifungal and Antibacterial Agents Based on 5-Aryl-2,2′-bipyridines and Their Heteroligand Salicylate Metal Complexes: Synthesis, Bioevaluation, Molecular Docking

A series of new 5-aryl-2,2′-bipyridines and their (polyfluoro)salicylate complexes of Cu(II), Co(II) and Mn(II) were synthesized. Their antimicrobial activity was evaluated in vitro against six strains of Trichophytons, E. floccosum, M. canis, C. ablicans and Gram-negative bacteria N. gonorrhoeae. Among azo-ligands, Ph-bipy and Tol-bipy showed promising antifungal activity (minimum inhibitory concentration (MIC)4?2H)2(Tol-bipy)2] suppressed the growth of seven Candida strains at MIC 12–24 μM. [Cu(Sal?2H)(Ph-bipy)] and [Cu(SalF3?2H)(Ph-bipy)2] showed the promising anti-gonorrhoeae activity (MIC 4.2–5.2 μM). (Cu(SalFn?2H)(Tol-bipy)2], [Cu(SalF4?2H)(Ph-bipy)2] and [Cu(SalF3?2H)(Ph-bipy)2]) were found active against the bacteria of S. aureus, S. aureus MRSA and their biofilms (MIC 2.4–41.4 μM). The most active compounds were tested for toxicity in vitro against human embryonic kidney (HEK-293) cells and in vivo experiments with CD-1 mice.

The discovery of pyridinium 1,2,4-triazines with enhanced performance in bioconjugation reactions

1,2,4-Triazines have recently been identified as versatile dienes participating in the inverse electron-demand Diels-Alder reaction with strained dienophiles. However, their widespread utility in bioconjugation reactions is still limited. Herein, we repor

Alternative Route Toward Nitrones: Experimental and Theoretical Findings

Nitrones are important building blocks for natural and biologically active compounds, used as spin-trap reagents and therapeutic agents. All this makes nitrones intriguing and valuable compounds for fundamental studies and as useful chemicals in various s

Facile synthesis of 6-aryl-3-pyridyl-1,2,4-triazines as a key step toward highly fluorescent 5-substituted bipyridines and their Zn(II) and Ru(II) complexes

A wide series of substituted bipyridines were obtained through the synthesis of 1,2,4-triazines and their aza Diels-Alder reactions. The reported method facilitates the synthesis of functionally diverse bipyridines that provides fine-tuning of photophysical properties of new ligands and their Zn(II) and Ru(II) complexes. Some of substituted bipyridines exhibit 'off-on' fluorescence response toward Zn2+ cations.

From 1,2,4-triazines towards substituted pyridines and their cyclometallated Pt complexes

A new, efficient methodology for the synthesis of substituted thienylpyridines includes the synthesis of 3-thienyl-1,2,4-triazines using simple heterocyclisation followed by easy transformation of the triazine ring to a pyridine through an aza Diels-Alder approach. A variety of substituted pyridines can be easily achieved using cheap, commercially available reagents such as bromoacetylarenes, aroyl hydrazides, norbornadiene, and enamines in various combinations. New thienylpyridines form phosphorescent cyclometallated Pt complexes.

Tandem oxidation processes for the regioselective preparation of 5-substituted and 6-substituted 1,2,4-triazines

α-Hydroxyketones undergo MnO2-mediated oxidation, followed by in situ trapping with 2-pyridylamidrazone, to give 3-pyridyl-5-substituted 1,2,4-triazines in a one-pot procedure, which avoids the need to isolate the reactive α-ketoaldehyde interm

An efficient route to 5-(hetero)aryl-2,4′- and 2,2′-bipyridines through readily available 3-pyridyl-1,2,4-triazines

A new route to substituted bipyridines based on a new method for the synthesis of substituted 3-pyridyl-1,2,4-triazines and their aza-Diels-Alder reactions is shown to be an efficient strategy for the preparation of structurally diverse bipyridine ligands.