850142-73-3

Basic information

• Product Name: 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE
• Synonyms: 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE
• CAS NO: 850142-73-3
• Molecular Formula: C6H5BrFNO
• Molecular Weight: 206.02
• Mol File: 850142-73-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 257℃
• Flash Point: 109℃
• Appearance: /
• Density: 1.621
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: -6.77±0.10(Predicted)
• CAS DataBase Reference: 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE(850142-73-3)
• EPA Substance Registry System: 6-BROMO-2-FLUORO-3-METHOXYPYRIDINE(850142-73-3)

Safety Data

• Hazardous Substances Data: 850142-73-3(Hazardous Substances Data)

Usage

General Description

6-Bromo-2-fluoro-3-methoxypyridine is a chemical compound with the molecular formula C6H5BrFNO. It is a pyridine derivative with a bromine atom at the 6th position, a fluorine atom at the 2nd position, and a methoxy group at the 3rd position. 6-Bromo-2-fluoro-3-methoxypyridine is used as a building block in the synthesis of pharmaceutical and agrochemical products. It is also used as an intermediate in the production of various organic compounds. 6-Bromo-2-fluoro-3-methoxypyridine has potential applications in the field of medicinal chemistry and drug discovery. It is important for its unique chemical structure and reactivity in organic synthesis.

InChI:InChI=1/C6H5BrFNO/c1-10-4-2-3-5(7)9-6(4)8/h2-3H,1H3

Upstream product

• 174669-74-0 2-fluoro-3-hydroxypyridine 
• 850142-72-2 6-bromo-2-fluoropyridin-3-ol 
• 124-41-4 sodium methylate 
• 74-88-4 methyl iodide 

Downstream Products

• 1438286-73-7 2-fluoro-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine 

Relevant articles and documents

N-CYCLYL-SULFONAMIDES USEFUL FOR INHIBITING RAF

This disclosure provides compounds and pharmaceutically acceptable salts thereof of Formula I (Formula I) The variables, e.g. R1-R4, and Z are defined herein. Y is Y is (II). Certain compounds of Formula I are highly potent against resistant tumor cell lines driven by BRAFV600E monomer melanoma cells (A375 or SK-MEL-239), p61-BRAFV600E dimer splice variant melanoma cells (SK-MEL-239-C4) and colorectal (RKO) and lung cancer (A549) cells, and at the same time display a highly desirable pharmacological profile in a mice tumor model.

An efficient coupling of N-tosylhydrazones with 2-halopyridines: Synthesis of 2-α-styrylpyridines endowed with antitumor activity

The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN) 2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine tBu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing 2-α-styrylpyridines 2 in satisfactory to good yields. Among several polyoxygenated derivatives 2 evaluated, compound 2aa was found to exhibit excellent antiproliferative and antimitotic activities comparable to that of the reference compound isoCA-4. The Royal Society of Chemistry 2013.

1-‘2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL!-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS

This invention provides a compound of the formula (I), wherein R1 and R2 independently represents a hydrogen atom or the like; R3 represents an aryl group having from 6 to 10 ring carbon or the like; said aryl groups havin