850142-73-3

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
6-Bromo-2-fluoro-3-methoxypyridine is used as a building block in the synthesis of pharmaceutical and agrochemical products. Its unique structure and reactivity make it a valuable component in the development of new drugs and agrochemicals.
Used in Organic Synthesis:
6-Bromo-2-fluoro-3-methoxypyridine is used as an intermediate in the production of various organic compounds. Its versatility in organic synthesis allows for the creation of a wide range of chemical products.
Used in Medicinal Chemistry and Drug Discovery:
6-Bromo-2-fluoro-3-methoxypyridine has potential applications in the field of medicinal chemistry and drug discovery. Its unique properties and reactivity contribute to the development of novel therapeutic agents and the advancement of pharmaceutical research.

InChI:InChI=1/C6H5BrFNO/c1-10-4-2-3-5(7)9-6(4)8/h2-3H,1H3

Upstream product

• 850142-72-2 6-bromo-2-fluoropyridin-3-ol 
• 124-41-4 sodium methylate 
• 74-88-4 methyl iodide 
• 174669-74-0 2-fluoro-3-hydroxypyridine 

Downstream Products

• 1438286-73-7 2-fluoro-3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine 

Relevant academic research and scientific papers

N-CYCLYL-SULFONAMIDES USEFUL FOR INHIBITING RAF

This disclosure provides compounds and pharmaceutically acceptable salts thereof of Formula I (Formula I) The variables, e.g. R1-R4, and Z are defined herein. Y is Y is (II). Certain compounds of Formula I are highly potent against resistant tumor cell lines driven by BRAFV600E monomer melanoma cells (A375 or SK-MEL-239), p61-BRAFV600E dimer splice variant melanoma cells (SK-MEL-239-C4) and colorectal (RKO) and lung cancer (A549) cells, and at the same time display a highly desirable pharmacological profile in a mice tumor model.

COMT INHIBITING METHODS AND COMPOSITIONS

Compounds that inhibit COMT enzyme and pharmaceutical compositions comprising the same are provided herein. Methods of treating various psychiatric and neurological disorders with the compounds and pharmaceutical compositions described herein are also provided.

An efficient coupling of N-tosylhydrazones with 2-halopyridines: Synthesis of 2-α-styrylpyridines endowed with antitumor activity

The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN) 2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine tBu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing 2-α-styrylpyridines 2 in satisfactory to good yields. Among several polyoxygenated derivatives 2 evaluated, compound 2aa was found to exhibit excellent antiproliferative and antimitotic activities comparable to that of the reference compound isoCA-4. The Royal Society of Chemistry 2013.

FUSED LACTAM COMPOUNDS

This invention provides a compound the formula (I), wherein R1 represents an aryl group having from 6 to 10 ring carbon atoms etc.; R2 represents a hydrogen atom etc., n epresents 0, 1 or 2; said heteroaryl group is unsubstituted or

1-‘2-(4-HYDROXYPHENYL)-2-HYDROXYETHYL!-PIPERIDIN-4-OL COMPOUNDS AS NMDA RECEPTOR ANTAGONISTS

This invention provides a compound of the formula (I), wherein R1 and R2 independently represents a hydrogen atom or the like; R3 represents an aryl group having from 6 to 10 ring carbon or the like; said aryl groups havin