85046-00-0

Upstream product

• 140-87-4 Cyanoacetohydrazide 
• 15725-17-4 3-(4-methoxybenzylidene)-2,4-pentanedione 
• 2286-29-5 ethyl 2-cyano-3-(4-methoxyphenyl)prop-2-enoate 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 52693-87-5 4-methylbenzaldehyde hydrazone 
• 4452-08-8 cyanoketene 
• 184582-43-2 4-Amino-3-phenyl-2-thioxo-2,3-dihydro-thiazole-5-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 184582-46-5 [4-Amino-5-[1-(4-methoxy-phenyl)-meth-(E)-ylidene-hydrazinocarbonyl]-3-phenyl-3H-thiazol-(2Z)-ylidene]-cyano-acetic acid ethyl ester 
• 184582-45-4 4-amino-2-dicyanomethylidene-5-(4-methoxybenzylidenehydrazinocarbonyl)-3-phenyl-2,3-dihydrothiazole 
• 184582-51-2 6-{[1-(4-Methoxy-phenyl)-meth-(E)-ylidene]-amino}-3-phenyl-2-thioxo-2,3-dihydro-6H-thiazolo[4,5-d]pyrimidin-7-one 
• 79388-07-1 1,6-diamino-4-(4-methoxyphenyl)-2-oxo-1,2-dihydropyridine-3,5-dicarbonitrile 
• 184582-44-3 4-Amino-2-thioxo-3-p-tolyl-2,3-dihydro-thiazole-5-carboxylic acid [1-(4-methoxy-phenyl)-meth-(E)-ylidene]-hydrazide 
• 85046-02-2 α-Cyano-β-(1-pyrenyl)-acrylsaeure-(4-methoxybenzyliden)-hydrazid 

Relevant academic research and scientific papers

Methylene Components Exchange in the Reaction of Cyanoacetohydrazide with 2-Amino-4-arylbuta-1,3-diene-1,1,3-tricarbonitriles

Abstract: 2-Amino-4-arylbuta-1,3-diene-1,1,3-tricarbonitriles obtained by Knoevenagel condensation between aldehydes and malononitrile dimer reacted with cyanoacetohydrazide in the presence of bases to afford N’-arylidene-2-cyanoacethydrazides instead of

The Complex Reaction of Acetohydrazides with Unsaturated Diketones: Alternative Cyclizations to 1,2-Diazepin-3-ones and Pyrazolopyridines

The reaction of 2-cyanoacetohydrazide (1) and 2-(ethoxycarbonyl)acetohydrazide (26) with unsaturated 1,3-diketones leading with moderate yields to 1,2-diazepinones (3, 23, 24) and pyrazolopyridines (5, 15, 20, 25) together with the corresponding acetohydrazones have been studied.The reaction course depends on the temperature and the relative reactivity of the carbonyl groups of the starting materials.When one of these carbonyl groups is less reactive (benzoyl or ethoxycarbonyl groups), the reaction does not yield diazepinones but only pyrazolopyridines and/or acetohydrazones.

Reaction of α-Cyano-β-aryl Acrylic Acid Ethylesters with Hydrazine, a Retro-Knoevenagel-Reaction

We tried to obtain 4-cyano 5-aryl pyrazolidones-(3) 3a, b and related azomethine imines 4a, b.However the reaction of α-cyano β-aryl acrylic acid ethylesters 2a, b with hydrazine yields the familiar cyano acetic acid arylidene hydrazides 5a, b by cleavage