85048-23-3Relevant academic research and scientific papers
Tandem Michael-Wittig Horner reaction one-pot synthesis of δ-substituted α,β-unsaturated esters
Piva, Olivier,Comesse, Sebastien
, p. 7191 - 7194 (2007/10/03)
A direct synthesis of δ-substituted α,β-unsaturated esters from unsubstituted aldehydes or ketones has been accomplished in high yield by a tandem 1,4-addition and Wittig-Horner reaction. The Copper-enolate obtained after the first step was able to deprotonate the highly addic phosphonate generating thus the two components necessary for the second coupling reaction.
Asymmetric Carboalkoxyalkylidenation with a Chiral Horner-Wadsworth-Emmons Reagent
Denmark, Scott E.,Rivera, Isaac
, p. 6887 - 6889 (2007/10/02)
The asymmetric carboalkoxyalkylidenation of 4-substituted cyclohexanones was effected by the use of chirally modified Horner-Wadsworth-Emmons (HWE) reagents in good yields (78-82percent) as well as high levels of enantioselectivity (78-86percent ee).
EFFICIENT OLEFINATION WITH α-ALKYL CYCLIC PHOSPHONAMIDES
Hanessian, Stephen,Bennani, Youssef L.,Leblanc, Yves
, p. 1411 - 1424 (2007/10/02)
A variety of acyclic and cyclic aldehydes and ketones can be converted into the corresponding alkylidene, benzylidene and methoxycarbonyl alkylidene derivatives by treatment with 1,3,2-diazaphospholidine-2-alkyl-1,3-dimethyl 2-oxides (α-alkyl cyclic phosphonamides) under mild conditions.This olefination method is particularly useful in the case of enolizable carbonyl compounds.
Regioselective Photocycloadditions of Benzoquinones to Alkylidenecyclohexanes: A New Synthetic Resource
Ciufolini, Marco A.,Rivera-Fortin, M. Angelica,Byrne, Norman E.
, p. 3505 - 3508 (2007/10/02)
Benzoquinones add regioselectively to alkylidenecyclohexanes.The photoadducts are converted into useful building blocks in good yield.
A New Synthesis of α,β-Unsaturated Carboxylic Esters Using Dialkyltelluronium Carbethoxymethylide
Osuka, Atsuhiro,Mori, Yasuo,Shimizu, Hirohito,Suzuki, Hitomi
, p. 2599 - 2602 (2007/10/02)
Dialkyltelluronium carbethoxymethylide was found to condense with a variety of carbonyl compounds to yield α,β-unsaturated carboxylic esters in good yields.
