85079-06-7Relevant academic research and scientific papers
Copper-catalyzed chemoselective oxidative o-aroylation of 2-acetylphenols, alkyl salicylates and 1,3-dicarbonyl compounds using styrene derivatives
Kumar, Upendra,Sharma, Ajay,Kumar, Naveen,Pandey, Satyendra Kumar
, (2021/03/03)
A novel copper-catalyzed chemoselective oxidative O-aroylation of 2-acetylphenols, alkyl salicylates and 1,3-dicarbonyl compounds with a wide range of styrene derivatives are described. This approach provides an efficient chemoselective preparation of phenol, alkyl salicylate and enol esters in good to excellent yields. This method represents an alternative protocol for the classical esterification reactions.
Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones
Ullah Mughal, Ehsan,Ayaz, Muhammad,Hussain, Zakir,Hasan, Aurangzeb,Sadiq, Amina,Riaz, Muhammad,Malik, Abdul,Hussain, Samreen,Choudhary, M. Iqbal
, p. 4704 - 4711 (2007/10/03)
Synthesis of flavones, 4-thioflavones and 4-iminoflavones was carried out with the substitution of variable halogens, methyl, methoxy and nitro groups in the A, B and AB rings of the respective compounds and we also report here their antibacterial activity. Most of the synthesized compounds were found to be active against Escherichia coli, Bacillus subtilis, Shigella flexnari, Salmonella aureus, Salmonella typhi and Pseudomonas aeruginosa. Activity of 4-thioflavones and 4-iminoflavones was found to be higher than that of their corresponding flavone analogues. Investigated compounds having substituents like F, OMe and NO2 at 4′-position in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antibacterial activity.
Synthesis and Biological Evaluation of Substituted Flavones as Gastroprotective Agents
Ares, Jeffrey J.,Outt, Pamela E.,Randall, Jared L.,Murray, Peter D.,Weisshaar, Pamela S.,et al.
, p. 4937 - 4943 (2007/10/03)
Flavone (1) was found to protect against ethanol-induced gastric damage in rats; however, it is known that certain compounds in the flavone class, including flavone itself, are inducers of hepatic drug metabolizing enzymes.With the hope identifying gastro
Reactions of Carbonyl Compounds in Basic Solutions. Part 11. The Baker-Venkataraman Rearrangement
Bowden, Keith,Chehel-Amiran, Mohsen
, p. 2039 - 2044 (2007/10/02)
The detailed mechanism of the Baker-Venkataraman rearrangement has been studied.The kinetics of the rearrangement of a series of 2-acetylphenyl 3- or 4-substituted benzoates and acetylnaphthyl benzoates catalysed by a basic 'non-nucleophilic' buffer in dimethyl sulphoxide have been measured.Studies of substituent effects, kinetic isotope effects, and acidity function correlations indicate a pathway involving pre-equilibrium formation of the carbanion, followed by rate-determining intramolecular nucleophilic attack.The methanolysis of the 2-acetylphenyl benzoates catalysed by methoxide in methanolic dimethyl sulphoxide has been similary investigated.In this case the pathway appears to involve neighbouring group participation by the ketonic carbonyl group.
Synthesis and characterization of 2-(2-hydroxyphenyl)-4-aryl-1,5-benzodiazepines
Lin,Hoch
, p. 640 - 642 (2007/10/02)
Four benzodiazepine derivatives, reported earlier by other authors, were resynthesized and characterized by NMR, IR, GC/MS and elemental analysis. Three of the four compounds have melting points different from those initially reported by 35-70° C. The dif
