851-78-5

Basic information

• Product Name: N-phenylsulfonyl-1,1-diphenylmethylamine
• Synonyms: N-phenylsulfonyl-1,1-diphenylmethylamine
• CAS NO: 851-78-5
• Molecular Weight: 323.415
• Mol File: 851-78-5.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: N-phenylsulfonyl-1,1-diphenylmethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenylsulfonyl-1,1-diphenylmethylamine(851-78-5)
• EPA Substance Registry System: N-phenylsulfonyl-1,1-diphenylmethylamine(851-78-5)

Safety Data

• Hazardous Substances Data: 851-78-5(Hazardous Substances Data)

Upstream product

• 13909-34-7 N-benzylidenephenylsulfonamide 
• 98-80-6 phenylboronic acid 
• 98-10-2 benzenesulfonamide 
• 91-01-0 1,1-Diphenylmethanol 
• 574-42-5 benzhydryl ether 
• 873-55-2 sodium benzenesulfonate 
• 91-00-9 Benzhydrylamine 
• 101-81-5 Diphenylmethane 
• 776-74-9 Bromodiphenylmethane 
• 90-99-3 diphenylchloromethane 
• 21160-02-1 benzophenone O-acetyl oxime 
• 574-66-3 Benzophenone oxime 
• 143-66-8 sodium tetraphenyl borate 
• 934-56-5 trimethyl(phenyl)stannane 

Relevant articles and documents

An efficient metal-free oxidative esterification and amination of benzyl C-H bond

An esterification and amination of benzylic C-H bonds was developed by using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) under metal- and iodide-free conditions. Both carboxylic acids and amines could be used as ideal coupling partners for the oxidati

Reaction Route and Mechanism of the Direct N-Alkylation of Sulfonamides on Acidic Mesoporous Zeolite β-Catalyst

Development of highly active heterogeneous catalysts with strong acidity and mesoporous structure is a highly attractive strategy for organic synthesis. In this study, a mesoporous zeolite beta (HBeta-M) with bulky particle size and strong acidity was synthesized and used in the direct N-alkylation of sulfonamides with alcohols. The strongly acidic HBeta-M had a higher intrinsic activity with initial turnover frequency of 11 × 10-2 s-1 than those of H-form mordenite nanosheets (3.3 × 10-2 s-1) and montmorillonite (4.0 × 10-2 s-1) catalysts. The experiment and characterization results demonstrate that there are two parallel reaction routes on the acidic catalysts. One route is the reaction of benzhydrol with p-toluenesulfonamide (route I). Another route is the reaction of dibenzhydryl ether, arising from route I, with p-toluenesulfonamide (route II), which is found in this work. The reaction rate of route I (13 × 10-3 mol kg-1 s-1) was higher than that of route II (9.8 × 10-3 mol kg-1 s-1) on HBeta-M, but route II predominantly contributed to the formation of the target product with high selectivity. Hereby, a complete reaction mechanism is proposed in this work.

Selective catalytic Hofmann: N -alkylation of poor nucleophilic amines and amides with catalytic amounts of alkyl halides

Using only catalytic amounts of alkyl halides in the reactions of poor nucleophilic amines/amides and alcohols led to a selective Hofmann N-alkylation reaction catalytic in alkyl halides, providing a practical and efficient method for the practical synthesis of mono- or di-alkylated amines/amides in high selectivities. This new method avoids the use of large amounts of bases, alkyl halides, and solvents, and generates water as the only byproduct. Preliminary mechanistic studies showed that alkyl halides are key intermediates/catalysts regeneratable in the reaction cycle.