85106-60-1

Upstream product

• 2466-76-4 N-Acetylimidazole 
• 100-39-0 benzyl bromide 

Downstream Products

• 28165-71-1 2,6-dichlorophenyl acetate 
• 4238-71-5 1-benzylimidazole 
• 29823-47-0 N-benzyl-N-methylacetamide 
• 2198-53-0 N-(2,6-dimethylphenyl)acetamide 
• 16238-16-7 N,N-Dipentylacetamide 
• 140-11-4 Benzyl acetate 
• 877-95-2 methyl-N-(benzyl-methyl)-formamide 
• 934-87-2 S-phenyl thioacetate 
• 5240-32-4 1-acetoxy-1-ethynyl cyclohexane 
• 103-45-7 acetic acid phenethyl ester 
• 103-54-8 cinnamyl acetate 
• 140-39-6 1-acetoxy-4-methylbenzene 
• 108-84-9 4-methyl-2-pentyl acetate 
• 618-42-8 1-piperidin-1-yl-ethanone 

Relevant academic research and scientific papers

An improved and convenient procedure for the synthesis of 1-substituted imidazoles

1-Protected imidazoles, such as 1-acetyl- and 1-benzoylimidazoles, react with various halides, such as benzyl, allyl, α-keto, and alkyl halides, to give 1-protected-3-substituted imidazolium salts in high yields. The resultant imidazolium salts are easily deprotected by treatment with water or alcohols to give the corresponding 1-substituted imidazoles in excellent yields. In this reaction the yields of 1-substituted imidazoles vary with the kinds of halides used and/or with the protecting groups, and the yields increase in the following order: benzyl halides≥allyl halides~α-keto halides>alkyl halides, and acetyl≥benzoyl>ethoxycarbonyl>diethoxymethyl>trimethylsilyl>tosyl.

1-ACYL-3-SUBSTITUTED IMIDAZOLIUM SALTS AS HIGHLY REACTIVE ACYLATING AGENTS

1-Acylimidazoles could be highly activated for acylation by the quarternizing with benzyl halides. 1-Acyl-3-benzylimidazolium halides were powerful acylating agents.Alcohols, phenols, and amines were converted to the corresponding esters and amides in excellent yields under mild conditions.Keywords - 1-acyl-3-substituted imidazolium salts; acylating agents; 1-acylimidazoles; 1-acetyl-3-benzylimidazolium bromide; 1-benzoyl-3-benzylimidazolium bromide