85156-99-6

Upstream product

• 24721-26-4 4-chlorochalcone 
• 141-97-9 ethyl acetoacetate 
• 956-04-7 3-(4-chlorophenyl)-1-phenylprop-2-en-1-one 

Relevant academic research and scientific papers

Mechanochemical michael reactions of chalcones and azachalcones with ethyl acetoacetate catalyzed by K2CO3 under solvent-free conditions

Michael addition reactions of chalcones and azachalcones with ethyl acetoacetate have been successfully performed in the presence of catalytic amount of K2CO3 (10 mol %) and under the high-speed vibration milling conditions. The reac

Reaction between Chalcones, 1,3-Dicarbonyl Compounds, and Elemental Sulfur: A One-Pot Three-Component Synthesis of Substituted Thiophenes

A simple and atom-economic synthesis of highly substituted thiophenes is demonstrated. Heating a solution of a chalcone and a linear/cyclic 1,3-dicarbonyl compound with elemental sulfur in CH 3 CN in the presence of NEt 3 at 80 °C af

Potassium phosphate-ionic liquid mediated selective mono-Michael addition

A simple and efficient process for an exclusive mono-Michael addition of active methylene compounds to conjugated esters, nitriles and ketones is developed. An ionic liquid-mediated reaction is carried out at room temperature. A reaction carried out at 60 °C resulted in a double-addition product. A mechanism is proposed and supported by P31 and DOSY NMR analysis of the used ionic liquid.

Tetraethylammonium superoxide induced Michael addition of active methylene compounds to chalcones

Michael addition of active methylene compounds to chalcones using in-situ generated tetraethylammonium superoxide results in the formation of Michael adducts in 69-84% yield under mild reaction conditions, at room temperature.

A mild, efficient, and green procedure for Michael addition of active methylene compounds to chalcones under microwave irradiation

A simple, rapid, and highly efficient method has been developed for the Michael addition of active methylene compounds to chalcones using potassium carbonate and water under microwave irradiation. The method is totally exempt of organic solvents, and pure

Highly Efficient Mechanochemical Reactions of 1,3-Dicarbonyl Compounds with Chalcones and Azachalcones Catalyzed by Potassium Carbonate

Under the high-speed vibration milling conditions, K20CO 3 was found to be a very efficient catalyst for the solvent-free Michael reactions of 1,3-dicarbonyl compounds with chalcones and azachalcones. In most cases, conventional side

Michael additions of active methylene compounds to chalcones promoted by samarium(III) iodide

Promoted by SmI3, α,β-unsaturated ketones reacted with malononitrile, ethylcyanoacetate, diethylmalonate, β-ketoester or nitromethane to give the 1,4-adducts in moderate to good yields.