85163-16-2

Basic information

• Product Name: 3-benzylcyclopentan-1-one
• Synonyms: 3-benzylcyclopentan-1-one
• CAS NO: 85163-16-2
• Molecular Weight: 174.243
• Mol File: 85163-16-2.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 3-benzylcyclopentan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-benzylcyclopentan-1-one(85163-16-2)
• EPA Substance Registry System: 3-benzylcyclopentan-1-one(85163-16-2)

Safety Data

• Hazardous Substances Data: 85163-16-2(Hazardous Substances Data)

Upstream product

• 22627-70-9 3-ethoxycyclopent-2-en-1-one 
• 930-30-3 cyclopent-2-enone 
• 5281-18-5 benzaldehyde, hydrazone 
• 100-52-7 benzaldehyde 
• 67100-39-4 3-benzyl-2-cyclopenten-1-one 
• 20371-41-9 5-phenylvaleric acid chloride 
• 153788-36-4 3-benzyl-1-trimethylsilyloxylcyclopent-1-ene 
• 100-44-7 benzyl chloride 
• 120853-06-7 2-Benzyl-5-oxo-cyclopentanecarboxylic acid methyl ester 
• 129866-61-1 1-Diazo-6-phenylhexan-2-one 

Relevant articles and documents

Ground-State Electron Transfer as an Initiation Mechanism for Biocatalytic C-C Bond Forming Reactions

The development of non-natural reaction mechanisms is an attractive strategy for expanding the synthetic capabilities of substrate promiscuous enzymes. Here, we report an "ene"-reductase catalyzed asymmetric hydroalkylation of olefins using α-bromoketones as radical precursors. Radical initiation occurs via ground-state electron transfer from the flavin cofactor located within the enzyme active site, an underrepresented mechanism in flavin biocatalysis. Four rounds of site saturation mutagenesis were used to access a variant of the "ene"-reductase nicotinamide-dependent cyclohexanone reductase (NCR) from Zymomonas mobiles capable of catalyzing a cyclization to furnish β-chiral cyclopentanones with high levels of enantioselectivity. Additionally, wild-type NCR can catalyze intermolecular couplings with precise stereochemical control over the radical termination step. This report highlights the utility for ground-state electron transfers to enable non-natural biocatalytic C-C bond forming reactions.

Asymmetric 1,4-reductions of and 1,4-additions to enoates and related systems

One aspect of the present invention relates to methods for the transition-metal-catalyzed asymmetric 1,4-addition of a nucleophile, e.g., hydride, to cyclic and acyclic enoates and enones. In certain embodiments of the methods of the present invention, th

Free Radical-Mediated Ketone Synthesis from Alkyl Iodides via Sequential Radical Acylation Approach

-