851645-63-1

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 6919-61-5 N-methoxy-N-methylbenzamide 
• 62-53-3 aniline 
• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 6048-29-9 triphenylphenacylphosphonium bromide 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 1678-18-8 (2-oxo-2-phenylethyl)-triphenylphosphonium chloride 
• 383-63-1 ethyl trifluoroacetate, 
• 1015-28-7 dimethyl (2-oxo-2-phenylethyl)phosphonate 
• 93-89-0 benzoic acid ethyl ester 

Downstream Products

• 1245905-61-6 (R)-5-(trifluoromethyl)-4,5-dihydro-5-(4-methoxyphenyl)-3-phenylisoxazole 
• 1380297-47-1 (R)-2-(4-methoxyphenyl)-4-oxo-4-phenyl-2-(trifluoromethyl)butanenitrile 
• 921932-51-6 4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenylbutan-1-one 
• 1392505-28-0 (E)-4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenyl-2-buten-1-ol 
• 1020171-85-0 (3R)-4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenylbutan-1-one 

Relevant academic research and scientific papers

Base-promoted isomerization of CF3-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions

Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion.

Catalytic Enantioselective Conjugate Alkynylation of β-Aryl-β-trifluoromethyl Enones Constructing Propargylic All-Carbon Quaternary Stereogenic Centers

The enantioselective conjugate alkynylation of β-aryl-β-trifluoromethyl enones has been carried out using terminal alkynes and diethylzinc in the presence of 3,3′-bis(perfluorophenyl)BINOL as the chiral ligand to give the corresponding ketones bearing a t

Efficient and highly enantioselective construction of trifluoromethylated quaternary stereogenic centers via high-pressure mediated organocatalytic conjugate addition of nitromethane to β,β-disubstituted enones

A very effective high-pressure-induced acceleration of asymmetric organocatalytic conjugate addition of nitromethane to sterically congested β,β-disubstituted β-CF3 enones has been developed. A combination of pressure (8-10 kbar) and noncovalent catalysis with low-loading of chiral tertiary amine-thioureas (0.5-3 mol %) is shown to provide very efficient access to a wide range of γ-nitroketones containing trifluoromethylated all-carbon quaternary stereogenic centers in the β-position (80-97%, 92-98% ee).

Synthesis of β-CF3 ketones from trifluoromethylated allylic alcohols by ruthenium catalyzed isomerization

This work describes the optimization process for the synthesis of β-trifluoromethylated ketones from trifluoromethylated allylic alcohols. This transformation proceeds through a ruthenium catalyzed isomerization under mild conditions with high atom econom

Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: Mechanistic evidence for an enantiospecific pathway

Transfer news: A synthetic approach to chiral β-CF3- substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF3-bearing allylic alcohols by an intramol

Enantioselective synthesis of trifluoromethyl-substituted 2-isoxazolines: Asymmetric hydroxylamine/enone cascade reaction

(Figure Presented) Cuts both ways: The title reaction consists of an addition/cyclization/dehydration sequence and affords the biologically important chiral 3,5-diaryl-5-(trifluoromethyl)-2-isoxazolines 1 in excellent yields with high ee values. The flexi

New approaches to β-trifluoromethylated enone derivatives

β-Trifluoromethylated enaminones 1 were prepared stereospecifically or high stercoselectively in 31-92% yields from the reaction of Weinreb amides with trifluoropropynyl lithium, followed by quenching with H2O in the presence of amine derivativ