851645-63-1

Basic information

• Product Name: 2-Buten-1-one, 4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenyl-, (2E)-
• CAS NO: 851645-63-1
• Molecular Formula: C17H13F3O2
• Molecular Weight: 306.284
• Mol File: 851645-63-1.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 2-Buten-1-one, 4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenyl-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Buten-1-one, 4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenyl-, (2E)-(851645-63-1)
• EPA Substance Registry System: 2-Buten-1-one, 4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenyl-, (2E)-(851645-63-1)

Safety Data

• Hazardous Substances Data: 851645-63-1(Hazardous Substances Data)

Upstream product

• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 93-89-0 benzoic acid ethyl ester 
• 383-63-1 ethyl trifluoroacetate, 
• 1015-28-7 dimethyl (2-oxo-2-phenylethyl)phosphonate 
• 711-38-6 4'-methoxy-2,2,2-trifluoroacetophenone 
• 1678-18-8 (2-oxo-2-phenylethyl)-triphenylphosphonium chloride 
• 20913-05-7 (Benzoylmethylene)triphenylphosphorane 
• 6048-29-9 triphenylphenacylphosphonium bromide 
• 62-53-3 aniline 
• 6919-61-5 N-methoxy-N-methylbenzamide 

Downstream Products

• 1245905-61-6 (R)-5-(trifluoromethyl)-4,5-dihydro-5-(4-methoxyphenyl)-3-phenylisoxazole 
• 1020171-85-0 (3R)-4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenylbutan-1-one 
• 1380297-47-1 (R)-2-(4-methoxyphenyl)-4-oxo-4-phenyl-2-(trifluoromethyl)butanenitrile 
• 1392505-28-0 (E)-4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenyl-2-buten-1-ol 
• 921932-51-6 4,4,4-trifluoro-3-(4-methoxyphenyl)-1-phenylbutan-1-one 

Relevant articles and documents

Base-promoted isomerization of CF3-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions

Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion.

Efficient and highly enantioselective construction of trifluoromethylated quaternary stereogenic centers via high-pressure mediated organocatalytic conjugate addition of nitromethane to β,β-disubstituted enones

A very effective high-pressure-induced acceleration of asymmetric organocatalytic conjugate addition of nitromethane to sterically congested β,β-disubstituted β-CF3 enones has been developed. A combination of pressure (8-10 kbar) and noncovalent catalysis with low-loading of chiral tertiary amine-thioureas (0.5-3 mol %) is shown to provide very efficient access to a wide range of γ-nitroketones containing trifluoromethylated all-carbon quaternary stereogenic centers in the β-position (80-97%, 92-98% ee).

Ruthenium-catalyzed redox isomerization of trifluoromethylated allylic alcohols: Mechanistic evidence for an enantiospecific pathway

Transfer news: A synthetic approach to chiral β-CF3- substituted saturated carbonyl compounds has been developed in which ruthenium complexes efficiently catalyze the redox isomerization of CF3-bearing allylic alcohols by an intramol