921932-51-6Relevant articles and documents
A novel synthesis of trifluoromethylated multi-substituted alkenes via regio- and stereoselective Heck reaction of (E)-4,4,4-trifluoro-1-phenyl-2- buten-1-one
Konno, Tsutomu,Yamada, Shigeyuki,Tani, Akinori,Miyabe, Tomotsugu,Ishihara, Takashi
, p. 3025 - 3028 (2006)
Treatment of (E)-4,4,4-trifluoro-1-phenyl-2-buten-1-one with various aryldiazonium salts in the presence of a palladium catalyst led to a smooth Heck reaction, furnishing α-arylated adducts in good yields. Georg Thieme Verlag Stuttgart.
Base-promoted isomerization of CF3-containing allylic alcohols to the corresponding saturated ketones under metal-free conditions
Hamada, Yoko,Kawasaki-Takasuka, Tomoko,Yamazaki, Takashi
, p. 1507 - 1512 (2017/08/14)
Following to the computational expectation, our previously reported intriguing 1,3-proton shift of 4,4,4-trifluorobut-2-yn-1-ols was successfully extended to the 4,4,4-trifluorobut-2-en-1-ol system under metal-free conditions to afford the corresponding saturated ketones in high to excellent chemical yields using such a convenient and easy-to-handle base as DBU at the toluene refluxing temperature, and utilization of the corresponding optically active substrates unambiguously demonstrated that this transformation proceeded in a highly stereoselective fashion.
Regioselective 1,4-trifluoromethylation of α,β-unsaturated ketones via a S-(trifluoromethyl)diphenylsulfonium salts/copper system
Okusu, Satoshi,Sugita, Yutaka,Tokunaga, Etsuko,Shibata, Norio
supporting information, p. 2189 - 2193 (2013/11/19)
Regioselective conjugate 1,4-trifluoromethylation of α,β- unsaturated ketones by the use of shelf-stable electrophilic trifluoromethylating reagents, S-(trifluoromethyl)diphenylsulfonium salts and copper under mild conditions is described. A wide range of acyclic aryl-aryl-enones and aryl-alkyl-enones were converted into β- trifluoromethylated ketones in low to moderate yields.
