851879-31-7

Upstream product

• 19982-41-3 N'-(2-ethoxy-benzoyl)-hydrazinecarbodithioic acid; potassium salt 
• 75-15-0 carbon disulfide 
• 21018-13-3 2-ethoxybenzoic acid hydrazide 
• 134-11-2 2-ethoxybenzoic acid 
• 6290-24-0 ethyl 2-ethoxybenzoate 

Downstream Products

• 1013751-25-1 C₁₉H₁₈N₄O₂S 
• 1013793-55-9 3-(2-ethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b]-[1,3,4]-thiadiazine 
• 1013751-39-7 C₂₀H₂₀N₄O₃S 
• 1018856-30-8 C₂₀H₂₀N₄O₃S 
• 1013751-44-4 C₂₀H₂₀N₄O₃S 
• 1013793-50-4 C₁₉H₁₈N₄O₂S 
• 1013751-35-3 3-(2-ethoxyphenyl)-6-(4-methoxyphenyl)-7H-[1,2,4]-triazolo-[3,4-b]-[1,3,4]-thiadiazine 
• 1187818-73-0 3-(2,4-dinitrophenylthio)-5-(2-ethoxyphenyl)-4H-1,2,4-triazol-4-amine 
• 1400796-60-2 methyl 3α-(2-(4-amino-3-(2-ethoxyphenyl)-5-thioxo-4,5-dihydro-1,2,4-triazol-1-yl)acetoxy)-12α-hydroxycholanate 
• 1385777-08-1 C₂₆H₃₀N₄O₇S₂ 
• 1385777-00-3 C₃₄H₃₈N₄O₁₁S₂ 
• 1385776-92-0 C₃₂H₃₆N₄O₁₀S 

Relevant academic research and scientific papers

Synthesis using microwave irradiation, characterisation and antibacterial activity of Novel deoxycholic acid-triazole conjugates

Novel deoxycholic acid 3α-triazole conjugates based on methyl 3α-chloroacetoxy-12α-hydroxy-cholanate have been synthesised. The synthesis is accelerated by microwave irradiation under solvent free conditions in the presence of K2CO3. Some of these compounds were tested for antibacterial activity against B.subtilis, P.aeruginosa and S.aureus. The preliminary results indicated that these deoxycholic acid-triazole conjugates have good inhibitory effect against B.subtilis. All of the compounds were characterised by 1H NMR, IR, ESI-MS spectra and elemental analyses.

Synthesis and structure of novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group

Some novel 1,2,4-triazole derivatives containing the 2,4-dinitrophenylthio group have been synthesised in high yields by means of the reactions of 3-substituted-4-amino -1H-1,2,4-triazole-5(4H)-thiones or (S-3-aryl-4- (benzylideneamino)-1H-l,2,4-triazole-5(4H)-thiones with 1-chloro-2,4- dinitrobenzene. The (S-3-aryl-4-(benzylideneamino)-1H-1,2,4-triazole-5(4H)- thiones were prepared by the reaction of 4-amino-3-aryl-2H-1,2,4-triazole-3(4H)- thiones and diverse aromatic aldehydes. The 2, 4-dinitrophenyl group linked to the S atom, not to the N atom, was confirmed by the crystal structures. The structures of all the compounds were determined by elemental analysis, IR, MS, 1H NMR and 13C NMR.

Identification of a potent new chemotype for the selective inhibition of PDE4

A series of substituted 3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines were prepared and analyzed as inhibitors of phosphodiesterase 4 (PDE4). Synthesis, structure-activity relationships, and the selectivity of a highly potent analogue against related phosphodiesterase isoforms are presented.