852064-40-5

Upstream product

• 184370-59-0 (E)-1-iodo-4-phenyl-1-butene 
• 33598-22-0 1-Phenyl-3-methylprop-2-yne 
• 852064-26-7 (E)-dimethyl(phenyl)(4-phenylbut-1-en-1-yl)silane 
• 637-59-2 1-Bromo-3-phenylpropane 
• 93-97-0 benzoic acid anhydride 
• 142981-60-0 trimethyl(1-oxo-4-phenylbutyl)silane 

Downstream Products

• 1202400-32-5 (3Z,5Z)-1,8-diphenyl-3,5-diene-4,5-diyl dibenzoate 
• 98-86-2 acetophenone 
• 1202400-37-0 (Z)-4-phenylbut-1-en-1-yl benzoate 
• 119-61-9 benzophenone 
• 699007-96-0 2,2-dimethoxy-6-phenylhexan-3-one 
• 852064-46-1 2,2-diethoxy-6-phenylhexan-3-one 
• 852064-41-6 (Z)-2-oxo-6-phenylhex-3-en-3-yl benzoate 

Relevant academic research and scientific papers

Direct Access to α,β-Unsaturated Ketones via Rh/MgCl2-Mediated Acylation of Vinylsilanes

We report herein the facile and practical construction of α,β-unsaturated ketones via rhodium-catalyzed direct acylation of vinylsilanes with readily available and abundant carboxylic acids. This protocol features access to a diverse array of synthetically useful functionalities with moderate to excellent yields. More importantly, the late-stage functionalization of pharmaceuticals was also realized with synthetically useful yield.

Rhodium-catalyzed acylation of vinylsilanes with acid anhydrides

A catalytic acylation of vinylsilane with acid anhydride is accomplished by the use of [RhCl(CO)2]2, in which the transmetalation between vinylsilane and rhodium(I) carbonyl complex plays a key role. The application of this acylation reaction to (1-acyloxyvinyl)silanes provides synthetic methods for α-acyloxy enones, α-diketones, and their derivatives.

Rhodium-catalyzed acylation of vinylsilanes with acid anhydrides: Application to the transformation of α-acyloxy vinylsilanes to unsymmetrical 1,2-diketones

Acylation of vinylsilanes with acid anhydrides is catalyzed by [RhCl(CO)2]2 to give α,β-unsaturated ketones. The application of this catalytic system to the acylation of α-acyloxy vinylsilanes affords α-acyloxy enones in good yields, which are converted to unsymmetrical 1,2-diketones or their mono acetals.