852287-08-2

Upstream product

• 40310-33-6 α-[(4'-methoxyphenyl)]-2-thienylmethanol 
• 108-95-2 phenol 
• 98-03-3 thiophene-2-carbaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 

Downstream Products

• 1009808-08-5 C₂₂H₂₅NO₂S 
• 1009808-10-9 C₂₄H₂₉NO₂S 
• 1009808-12-1 C₂₆H₃₁NO₂S 
• 1009808-11-0 C₂₄H₂₇NO₃S 
• 1009808-34-7 C₂₁H₂₀O₃S 
• 1206894-15-6 1-(2-{4-[(4-methoxyphenyl)-thiophen-2-yl-methyl]phenoxy}ethyl)pyrrolidine 

Relevant academic research and scientific papers

Transition-Metal-Free Synthesis of Polyfunctional Triarylmethanes and 1,1-Diarylalkanes by Sequential Cross-Coupling of Benzal Diacetates with Organozinc Reagents

A variety of functionalized triarylmethane and 1,1-diarylalkane derivatives were prepared via a transition-metal-free, one-pot and two-step procedure, involving the reaction of various benzal diacetates with organozinc reagents. A sequential cross-coupling is enabled by changing the solvent from THF to toluene, and a two-step SN1-type mechanism was proposed and evidenced by experimental studies. The synthetic utility of the method is further demonstrated by the synthesis of several biologically relevant molecules, such as an anti-tuberculosis agent, an anti-breast cancer agent, a precursor of a sphingosine-1-phosphate (S1P) receptor modulator, and a FLAP inhibitor.

Thiophene containing trisubstituted methanes [TRSMs] as identified lead against Mycobacterium tuberculosis

Triarylmethanes (TRAMs) and thiophene containing trisubstituted methanes (TRSMs) have been reported by us, having potential against Mycobacterium tuberculosis and Mycobacterium fortuitum strains, respectively. Further, extension through synthesis and biol

Design, synthesis and antitubercular activity of compounds containing Aryl and heteroaryl groups with alkylaminoethyl chains

Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37RV and showed the activity in the range of 3.12-25 μg/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubcrcular activity. Among heteroaryl containing triarylmcthanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.

Thiophene containing triarylmethanes as antitubercular agents

A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-12.5 μg/mL in vitro.

An easy access to unsymmetric trisubstituted methane derivatives (TRSMs)

A new series of unsymmetric trisubstituted methane derivatives (TRSMs) has been synthesized through Friedel-Crafts alkylation of aromatic nucleophiles using acid-sensitive heteroaryl carbinols.