40310-33-6

Upstream product

• 83682-19-3 [2]thienyl sodium 
• 123-11-5 4-methoxy-benzaldehyde 
• 98-03-3 thiophene-2-carbaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 188290-36-0 thiophene 
• 13139-86-1 4-methoxyphenyl magnesium bromide 
• 3437-95-4 2-Iodothiophene 
• 4160-63-8 2-(4-methoxybenzoyl)thiophene 
• 5713-61-1 thiophen-2-yl magnesium bromide 

Downstream Products

• 135887-31-9 C₂₄H₂₂O₃S₂ 
• 1415210-11-5 C₁₅H₁₈O₂S 
• 1415210-10-4 C₂₅H₂₅NO₄S 
• 1582256-28-7 4-((4-methoxyphenyl)(thiophen-2-yl)methyl)aniline 
• 1582256-29-8 4-chloro-2-((4-methoxyphenyl)(thiophen-2-yl)methyl)-aniline 
• 852287-08-2 4-[(4-methoxy-phenyl)-thiophen-2-yl-methyl]-phenol 
• 852287-07-1 2-[(4-methoxy-phenyl)-thiophen-2-yl-methyl]-phenol 

Relevant academic research and scientific papers

Synthesis of arylcarbinols and/or arylketones end capped thiophene and 2,2′-bithiophene

Synthesis of arylmethanol of thiophene and 2,2′-bithiophene derivatives (4, 5, 8, 9 and 13) and the corresponding ketones (6, 10, 11 and 14) which were prepared by lithiation/addition exchange sequence on the arylbromides (2, 3 and 12) followed by trappin

Thiophene containing trisubstituted methanes [TRSMs] as identified lead against Mycobacterium tuberculosis

Triarylmethanes (TRAMs) and thiophene containing trisubstituted methanes (TRSMs) have been reported by us, having potential against Mycobacterium tuberculosis and Mycobacterium fortuitum strains, respectively. Further, extension through synthesis and biol

Synergistic stereoselective organocatalysis with indium(III) salts

The compatibility of indium(III) Lewis acids with water and amines allows their employment in synergistic and cooperative catalysis. Stereoselective organocatalytic SN1-type reactions, in which carbenium ions are generated, are promoted by the presence of indium salts. The peculiar properties of indium salts can be exploited in organocatalysis for the design of water-compatible, benign, green processes. The development of such indium(III)-promoted organocatalytic procedures is the focus of our recent research, a summary of which is presented in this article. Georg Thieme Verlag Stuttgart.New York.

Design, synthesis and antitubercular activity of compounds containing Aryl and heteroaryl groups with alkylaminoethyl chains

Aryl and heteroaryl derivatives with an alkylaminoethyl chain on the hydroxyl group of the benzene ring are prepared and evaluated against Mycobacterium tuberculosis H37RV and showed the activity in the range of 3.12-25 μg/mL. The compounds containing alkylaminoethyl chains on aryl-chromeneyl carbinol do not show good activity. Similarly compounds with bis and tris-alkylaminoethyl chains on aryl and triarylmethane derivatives do not exhibit antitubcrcular activity. Among heteroaryl containing triarylmcthanes (TRAMs), thiophene derivatives with alkylaminoethyl chain on aromatic hydroxyl group have exhibited good antitubercular activity. On the other hand, pyrrole containing TRAMs do not show good activity.

Thiophene containing triarylmethanes as antitubercular agents

A new series of thiophene containing triarylmethane derivatives were synthesized from the Friedel-Crafts alkylation of diarylcarbinols followed by incorporation of amino alkyl chains. These were evaluated against Mycobacterium tuberculosis H37Rv and showed the activity in the range of 3.12-12.5 μg/mL in vitro.

An easy access to unsymmetric trisubstituted methane derivatives (TRSMs)

A new series of unsymmetric trisubstituted methane derivatives (TRSMs) has been synthesized through Friedel-Crafts alkylation of aromatic nucleophiles using acid-sensitive heteroaryl carbinols.

Deprotonation of thiophenes using lithium magnesates

Thiophene was regioselectively deprotonated at C2 on treatment with 1/3 equiv of Bu3MgLi in THF at room temperature. The lithium arylmagnesate formed was either trapped with electrophiles or cross-coupled in a 'one-pot' procedure with aryl halides under palladium catalysis. 2-Chlorothiophene and 2-methoxythiophene were similarly deprotonated at C5 under the same reaction conditions. The enhancement of the reactivity of the base using TMEDA was evidenced using 1H NMR spectroscopy.

Photochemical reactions of Thienyl-, Bithienyl-, Terthienyl- and Thienylaroyl-methanols

Photochemical reactions of some thienyl-, bithienyl-, terthienyl- and thienylaroyl-methanols were studied in the neat state as well as in solvents like methanol and benzene.The terthienylmethanols were found to be susceptible to photo-sensitized oxidation which was inhibited by singlet oxygen quenchers.The photoproducts were isolated, characterised by spectroscopic methods and in some cases by synthesis.