852616-69-4

Upstream product

• 852616-66-1 tert-butyl (2R,3R,4S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-3,4-dihydroxypyrrolidine-1-carboxylate 
• 98-88-4 benzoyl chloride 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 
• 74844-93-2 N-BOC-3,4-didehydro-(S)-proline methyl ester 
• 205444-34-4 (S)-tert-butyl 2-(hydroxymethyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 84520-67-2 (2S,4R)-4-(methylsulfonyloxy)pyrrolidine-1,2-dicarboxylic acid 1-tert-butylester-2-methylester 
• 852616-64-9 tert-butyl (S)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,5-dihydro-1H-pyrrole-1-carboxylate 

Downstream Products

• 852616-72-9 (2R,4S)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-oxo-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 
• 852616-77-4 (2S,3R,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethyl-2-(tert-butyldimethylsiloxymethyl)pyrrolidine 
• 852616-74-1 (2S,3S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 
• 852616-75-2 (2S,3R,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 
• 852616-73-0 (2S,4R)-N-tert-butyloxycarbonyl-4-benzoyloxy-3-difluoromethylenyl-2-(tert-butyldiphenylsiloxymethyl)pyrrolidine 

Relevant academic research and scientific papers

Synthesis of 3′-deoxy-3′-difluoromethyl azanucleosides from trans-4-hydroxy-L-proline

Two strategies were tried to synthesize 3′-deoxy-3′- difluoromethyl azanucleosides. After the failure of the first route, the key intermediate 12 from trans-4-hydroxyproline 7 in 8 steps was stereoselectively prepared. The alcohol 12 was subjected to sele