852630-38-7Relevant academic research and scientific papers
Synthesis of α-hydroxycarboxylic acids from various aldehydes and ketones by direct electrocarboxylation: A facile, efficient and atom economy protocol
Singh, Kishanpal,Sohal, Harvinder Singh,Singh, Baljit
, p. 839 - 845 (2021/04/09)
In present work, the formation of α-hydroxycarboxylic acids have been described from various aromatic aldehydes and ketones via direct electrocarboxylation method with 80-92% of yield without any side product and can be purified by simple recrystallization using sacrificial Mg anode and Pt cathode in an undivided cell, CO2at (1 atm) was continuously bubbled in the cell throughout the reaction using tetrapropylammonium chloride as a supporting electrolyte in acetonitrile. The synthesized compounds obtained in fair to excellent yield with a high level of purity. The characterization of electrocarboxylated compounds was done with spectroscopic techniques like IR, NMR (1H & 13C), mass and elemental analysis.
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 0460; 0463; 0464, (2016/09/26)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 00837; 00839, (2015/09/28)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
N-heterocyclic carbenes mediated cyano-phosphorylation of ketones
He, Lin,Zhang, Jing,Fan, Ye-Cheng,Du, Guang-Fen,Zhang, Jie,Dai, Bin
supporting information, p. 5861 - 5864 (2013/10/21)
Cyanation-O-protection reaction of ketones with different cyanide sources catalyzed by N-heterocyclic carbenes is reported. Under the catalysis of 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene, various ketones coupled with diethyl cyanophosphonate to p
Electrochemical synthesis of α-hydroxycarboxylic acids from acetophenones
Khaja Lateef,Ramesh Raju,Krishna Mohan,Jayarama Reddy
, p. 31 - 36 (2007/10/03)
α-Hydroxy carboxylic acids are synthesized in 80-86% isolated yields by electrochemical carboxylation of methyl aryl ketones in the presence of carbon dioxide (1 atm.) using a platinum cathode and a sacrificial magnesium anode at a constant current density of 10 mA/cm2. Reversibility of the carbonyl group reduction and generation of anionic radical were shown by cyclic voltammetry. Copyright Taylor & Francis LLC.
Enantioselective cyanosilylation of ketones catalyzed by a chiral oxazaborolidinium ion
Do, Hyun Ryu,Corey
, p. 5384 - 5387 (2007/10/03)
The chiral oxazaborolidinium salt 1 (X = TfO) is an excellent catalyst for the cyanosilylation of methyl ketones promoted by trimethylsilyl cyanide and diphenylmethyl phosphine oxide as co-reactants (to generate Ph 2MePOTMS(N=C:) as a reactive
Non-steroidal antiandrogens. Design of novel compounds based on an infrared study of the dominant conformation and hydrogen-bonding properties of a series of anilide antiandrogens
Morris,Hughes,Glen,Taylor
, p. 447 - 455 (2007/10/02)
Antiandrogenic activity is observed in anilides containing a tertiary hydroxyl group, and these compounds are used to define a pharmacophore in terms of their physicochemical properties. Infrared spectroscopy shows that these anilides exist in a single co
