85274-64-2

Basic information

• Product Name: 6-CHLORO-3-PHENYL-2-QUINOLINOL
• Synonyms: 6-CHLORO-3-PHENYL-2-QUINOLINOL;6-Chloro-2-hydroxy-3-phenylquinoline
• CAS NO: 85274-64-2
• Molecular Formula: C₁₅H₁₀ClNO
• Molecular Weight: 255.7
• Mol File: 85274-64-2.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 473.9°C at 760 mmHg
• Flash Point: 240.4°C
• Appearance: /
• Density: 1.303g/cm³
• Vapor Pressure: 3.78E-09mmHg at 25°C
• Refractive Index: 1.641
• CAS DataBase Reference: 6-CHLORO-3-PHENYL-2-QUINOLINOL(CAS DataBase Reference)
• NIST Chemistry Reference: 6-CHLORO-3-PHENYL-2-QUINOLINOL(85274-64-2)
• EPA Substance Registry System: 6-CHLORO-3-PHENYL-2-QUINOLINOL(85274-64-2)

Safety Data

• Hazardous Substances Data: 85274-64-2(Hazardous Substances Data)

Usage

Chemical compound

6-CHLORO-3-PHENYL-2-QUINOLINOL

Family

Quinolinol

Properties

Contains a chloro group
Contains a phenyl group
Quinolinol ring structure

Pharmacological activities

Anti-inflammatory effects
Anti-bacterial effects

Potential uses

Drug development
Intermediate in pharmaceutical synthesis

Mechanism of action

Interaction with specific targets in the body

Overall significance

Compound of interest for potential pharmacological properties.

InChI:InChI=1/C15H10ClNO/c16-12-6-7-14-11(8-12)9-13(15(18)17-14)10-4-2-1-3-5-10/h1-9H,(H,17,18)

Upstream product

• 63069-48-7 p-chloro-o-iodoaniline 
• 536-74-3 phenylacetylene 
• 13939-06-5 molybdenum hexacarbonyl 
• 14313-60-1 6-chlorobenzo[c]isoxazole? 
• 100-44-7 benzyl chloride 
• 5551-11-1 4-Chloro-2-nitrobenzaldehyde 
• 6628-86-0 5-chloro-2-nitrobenzaldehyde 
• 260783-80-0 N,N,N--trimethyl--1--phenylmethanaminium trifluoromethanesulfonate 
• 103-83-3 N,N'-dimethylbenzylamine 
• 100-52-7 benzaldehyde 
• 144-62-7 oxalic acid 
• 1254211-89-6 C₁₅H₈ClN 
• 98-86-2 acetophenone 
• 1073-69-4 N-4-chlorophenylhydrazine 

Downstream Products

• 85274-46-0 2,6-dichloro-3-phenylquinoline 
• 85274-39-1 [2-(6-Chloro-3-phenyl-quinolin-2-ylsulfanyl)-ethyl]-dimethyl-amine 

Relevant articles and documents

Palladium-catalyzed carbonylative cyclization of benzyl chlorides with anthranils for the synthesis of 3-arylquinolin-2(1: H)-ones

An efficient carbonylative procedure for the synthesis of 3-arylquinoin-2(1H)-ones has been established. Through a palladium-catalyzed aminocarbonylation of benzyl chlorides with anthranils, a variety of 3-arylquinoin-2(1H)-one products were obtained in moderate to excellent yields with good functional group tolerance. This journal is

Palladium-catalyzed carbonylative synthesis of 3-arylquinolin-2(1H)-ones from benzyl chlorides and o-nitrobenzaldehydes

A palladium-catalyzed carbonylative cyclization of benzyl chlorides with o-nitrobenzaldehydes has been developed for the synthesis of 3-arylquinolin-2(1H)-ones. Mo(CO)6 played a dual role as both a CO surrogate and a reductant in this carbonylative transformation.

Supported Palladium Nanoparticles-Catalyzed Synthesis of 3-Substituted 2-Quinolones from 2-Iodoanilines and Alkynes Using Oxalic Acid as C1 Source

3-Aryl/alkyl-2-quinolones were synthesized employing microwave assisted multicomponent reaction of 2-iodoanilines, terminal alkynes and oxalic acid dihydrate ((CO2H)2 ? 2H2O) under polystyrene supported palladium (Pd@PS) nanoparticles-catalyzed conditions. The use of a heterogeneous palladium catalyst was explored first time for 2-quinolone synthesis involving carbonylation reaction employing (CO2H)2 ? 2H2O as a solid and bench stable carbon monoxide (CO) source. The reaction exhibited good substrate generality for 2-iodoanilines and alkynes with wide functional group tolerance and good regio-selectivity. The ligand free operation, recyclability of heterogeneous Pd@PS catalyst and use of bench stable C1 source are the invaluable merits of the protocol. (Figure presented.).