85296-08-8

Upstream product

• 92-52-4 biphenyl 
• 933-88-0 ortho-toluoyl chloride 
• 939-23-1 p-phenylpyridine 
• 577-16-2 2-Methylacetophenone 
• 26863-15-0 N-(2',4'-dinitrophenyl)-4-phenylpyridinium chloride 

Downstream Products

• 1981-38-0 2-phenylanthracene 
• 86428-85-5 Biphenyl-4-yl-{2-methyl-5-[4'-(2-methyl-benzoyl)-biphenyl-4-ylmethyl]-phenyl}-methanone 
• 79446-86-9 3-Biphenyl-4-yl-3-hydroxy-3-o-tolyl-propionic acid ethyl ester 
• 79446-93-8 3-Biphenyl-4-yl-3-hydroxy-3-o-tolyl-propionic acid 
• 79446-93-8 3-Biphenyl-4-yl-3-hydroxy-3-o-tolyl-propionic acid 
• 79446-93-8 (R)-3-Biphenyl-4-yl-3-hydroxy-3-o-tolyl-propionic acid 
• 118-90-1 ortho-methylbenzoic acid 
• 92-92-2 biphenyl-4-carboxylic acid 

Relevant academic research and scientific papers

Connecting a carbonyl and a π-conjugated group through a: P-phenylene linker by (5+1) benzene ring formation

A benzene ring was formed to connect a carbonyl group of various methyl ketones with a π-conjugated group through a p-phenylene linker. Methyl ketones and streptocyanines were used as the C1 and C5 sources, respectively, in the (5+1) annulation, which could form donor-π-acceptor molecules.

Imidazolylmethylbenzophenones as highly potent aromatase inhibitors

Suppression of tumor and plasma estrogen levels by inhibition of aromatase is one of the most effective treatments for post-menopausal breast cancer patients. Starting from an easy, synthetically accessible, benzophenone scaffold, a new class of potent aromatase inhibitors was synthesized, endowed with high selectivity with respect to 17α-hydroxylase/17,20-lyase (CYP17). Compounds 1b and 1d proved to be among the most potent inhibitors described so far.

Phthalocyanines and related compounds: XXXIX. Synthesis of derivatives of some substituted 1-phenylnaphthalene-2,3-dicarboxylic acids

Derivatives (dinitriles, anhydrides, imides, N-phenylimides) of substituted 1-phenylnaphthalene-2,3-dicarboxylic and 1-phenylphenanthrene-2,3-dicarboxylic acids were prepared by the reactions of 2-bromomethylbenzophenones with various dienophiles. Starting from these derivatives, gallium complexes of substituted tetra-1-phenyl-2,3-naphthalocyanines and tetra(1-phenyl-2,3-phenanthro) porphyrazine were synthesized. 2005 Pleiades Publishing, Inc.

Syntheses of Asymmetrical Diaryl and Aryl Alkyl Ketones as Possible Non-steroidal Antiprogestational Agents

A number of asymmetrical diaryl and aryl alkyl ketones have been synthesised as possible non-steroidal antiprogestational agents.Evaluation of these compounds as competitive inhibitors of progesterone binding to uterine cytosol progesterone receptors of rabbit and human indicates that 3-methyl-4'-phenylbenzophenone (2) exhibits marginal activity in both the cases.However, this compound has been found to be inferior to R 5020 and d-norgestrel.

Friedel-Crafts Aroylation of Benzene and Biphenyl in Methylene Chloride

Reactions of acid chlorides of o-, m- and p-toluic acids, p-methoxy- and 3,4-methylenedioxybenzoic acids with biphenyl in the presence of anhydrous AlCl3 in methylene chloride have been studied.Of these, only the reactions of o-, m- and p-toluoly chlorides with biphenyl indicates inter- and intramolecular methylene insertions in the reaction products.It is observed that the 2-, 3- and 4-methylbenzophenones, formed as intermediates, participate in the methylene insertion reactions.In a few cases, besides methylene insertion, methyl insertion has also occurred.Unlike these reactions, the reaction of o-toluoyl chloride with benzene in presence of anhydrous AlCl3 in methylene chloride gives 2-methyl-3-(p-benzylphenyl)benzophenone.The structural assignment of these products are made on the basis of their PMR and mass spectra.