852997-59-2Relevant articles and documents
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation
Lin, Ronghui,Lu, Yanhua,Wetter, Steven K.,Connolly, Peter J.,Turchi, Ignatius J.,Murray, William V.,Emanuel, Stuart L.,Gruninger, Robert H.,Fuentes-Pesquera, Angel R.,Adams, Mary,Pandey, Niranjan,Moreno-Mazza, Sandra,Middleton, Steven A.,Jolliffe, Linda K.
, p. 2221 - 2224 (2005)
A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa,