3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation

DOI: 10.1016/j.bmcl.2005.03.024

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2221 - 2224 (2005)

Update date:2022-08-05

Topics:

Authors:

Lin, Ronghui

Lu, Yanhua

Wetter, Steven K.

Connolly, Peter J.

Turchi, Ignatius J.

Murray, William V.

Emanuel, Stuart L.

Gruninger, Robert H.

Fuentes-Pesquera, Angel R.

Adams, Mary

Pandey, Niranjan

Moreno-Mazza, Sandra

Middleton, Steven A.

Jolliffe, Linda K.

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Article abstract of DOI:10.1016/j.bmcl.2005.03.024

A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa,

Full text of DOI:10.1016/j.bmcl.2005.03.024

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