852997-75-2Relevant academic research and scientific papers
AMINO SUBSTITUTED PYRIDINYL METHANONE COMPOUNDS USEFUL IN TREATING KINASE DISORDERS
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Page/Page column 37-39, (2010/02/11)
The present invention provides amino substituted pyridinyl methanone compounds; pharmaceutical compositions comprising the compounds and methods of synthesis thereof. The compounds, which are cyclin dependent kinase (CDK) inhibitors, can be used to treat
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: Synthesis and biological evaluation
Lin, Ronghui,Lu, Yanhua,Wetter, Steven K.,Connolly, Peter J.,Turchi, Ignatius J.,Murray, William V.,Emanuel, Stuart L.,Gruninger, Robert H.,Fuentes-Pesquera, Angel R.,Adams, Mary,Pandey, Niranjan,Moreno-Mazza, Sandra,Middleton, Steven A.,Jolliffe, Linda K.
, p. 2221 - 2224 (2007/10/03)
A novel series of 2,6-diamino-3-acylpyridines were designed and synthesized as cyclin-dependent kinase (CDK) inhibitors. The representative compounds 2r and 11 showed potent CDK1 and CDK2 inhibitory activities and inhibited cellular proliferation in HeLa,
