85301-38-8

Usage

Uses

Used in Pharmaceutical Industry:
5-Pyrimidineacetic acid, 2-amino-1,4-dihydro-4-oxo(9CI) is used as a key intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs and bioactive compounds. Its unique structure allows for the creation of a wide range of medicinal agents, enhancing the industry's capacity to address various health concerns.
Used in Drug Discovery Research:
In the realm of drug discovery, 5-Pyrimidineacetic acid, 2-amino-1,4-dihydro-4-oxo(9CI) serves as a valuable component in the design and synthesis of novel drug candidates. Its presence in these compounds can potentially lead to breakthroughs in the treatment of various diseases and conditions, making it an essential part of ongoing research efforts.
Used in Organic Chemistry:
5-Pyrimidineacetic acid, 2-amino-1,4-dihydro-4-oxo(9CI) is also used in organic chemistry for the synthesis of other organic compounds. Its versatile structure makes it a useful building block in the creation of a variety of chemical products, contributing to the advancement of the field and the development of new applications across multiple industries.

Upstream product

• 58026-12-3 dimethyl formylsuccinate 
• 50-01-1 guanidine hydrochloride 
• 107-31-3 Methyl formate 
• 106-65-0 Dimethyl succinate 
• 85301-39-9 Ethyl 2-(2-Amino-4-oxo-3,4-dihydro-5-pyrimidinyl) Acetate 

Relevant academic research and scientific papers

A Fmoc/Boc pseudoisocytosine monomer for peptide nucleic acid synthesis

The synthesis of N-[2-(fluorenylmethoxycarbonyl)aminoethyl]-N-[(2-N-(tert- butoxycarbonyl)isocytosin-5-yl)acetyl]glycine peptide nucleic acid monomer is described. The N-tert-butoxycarbonyl protected monomer is compatible with commercially available monomers designed for the Fmoc-oligomerization strategy and is deprotected under mild acidolysis conditions.

Peptide nucleic acids having antibacterial activity

Methods of and compositions for killing or inhibiting the growth of a bacteria are disclosed. The methods comprise the use of peptide nucleic acids that are targeted to mRNA and/or rRNA. In certain embodiments, methods include the use of one or more separate antibiotics.

Linked peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to the peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.

Peptide nucleic acids

Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be orientated either parallel or antiparallel to each other.

Antibacterial and antibiotic methods using peptide nucleic acids and pharmaceutical compositions therefor

Methods of and compositions for killing or inhibiting the growth of a bacteria are disclosed. The methods comprise the use of peptide nucleic acid that is targeted to mRNA and/or rRNA. In certain embodiments, methods include the use of one or more separate antibiotics.