85404-48-4

Basic information

• Product Name: (-)-Haplomyrfolin
• Synonyms: (-)-Haplomyrfolin
• CAS NO: 85404-48-4
• Molecular Formula: C₂₀H₂₀O₆
• Molecular Weight: 356.3692
• Mol File: 85404-48-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (-)-Haplomyrfolin(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-Haplomyrfolin(85404-48-4)
• EPA Substance Registry System: (-)-Haplomyrfolin(85404-48-4)

Safety Data

• Hazardous Substances Data: 85404-48-4(Hazardous Substances Data)

Usage

General Description

(-)-Haplomyrfolin is a natural chemical compound isolated from the fruiting bodies of the fungus Hapalopilus myceliosus. It is a sesquiterpene lactone with a unique tricyclic structure and possesses an array of biological activities. Studies have shown that (-)-Haplomyrfolin exhibits strong anti-inflammatory and antitumor properties, making it a potential candidate for the development of new drugs for the treatment of cancer and other inflammatory diseases. Additionally, it has also demonstrated significant antifungal activity against various pathogenic fungi. (-)-Haplomyrfolin has therefore attracted attention from the scientific community as a promising natural product with potential therapeutic applications.

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Relevant articles and documents

Modular synthesis and biological investigation of 5-hydroxymethyl dibenzyl butyrolactones and related lignans

Dibenzyl butyrolactone lignans are well known for their excellent biological properties, particularly for their notable anti-proliferative activities. Herein we report a novel, efficient, convergent synthesis of dibenzyl butyrolactone lignans utilizing the acyl-Claisen rearrangement to stereoselectively prepare a key intermediate. The reported synthetic route enables the modification of these lignans to give rise to 5-hydroxymethyl derivatives of these lignans. The biological activities of these analogues were assessed, with derivatives showing an excellent cytotoxic profile which resulted in programmed cell death of Jurkat T-leukemia cells with less than 2% of the incubated cells entering a necrotic cell death pathway.