855463-32-0

Upstream product

• 860361-30-4 1-phenethyl-5-phenyl-pyrrolidin-2-one 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 64-04-0 phenethylamine 
• 3230-65-7 3,4-dihydroisoquinoline 
• 13254-30-3 (phenylpropargyl)magnesium bromide 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 33603-87-1 (Z)-3-chloro-3-phenyl-2-propenal 
• 14804-59-2 (Z)-β-bromocinnamaldehyde 
• 98-86-2 acetophenone 

Downstream Products

• 20958-78-5 3-phenyl-pyrrolo[2,1-a]isoquinoline 

Relevant academic research and scientific papers

Base-Promoted Intermolecular Cyclization of Substituted 3-Aryl(Heteroaryl)-3-chloroacrylaldehydes and Tetrahydroisoquinolines: An Approach to Access Pyrrolo[2,1-a]isoquinolines

We have developed a new base-promoted intermolecular cascade cyclization reaction of substituted 3-aryl(heteroaryl)-3-chloroacrylaldehydes and tetrahydroisoquinolines in one pot. The reaction provides a facile and practical synthesis of pyrrolo[2,1-a]isoquinolines. A number of pyrrolo[2,1-a]isoquinolines were synthesized in moderate to high yields (up to 97%).

Silver(i)-promoted oxidative cyclisation to pyrrolo[2,1-a]isoquinolines and application to the synthesis of (±)-crispine A

The silver(i)-promoted oxidative cyclisation of 1-propargyl-substituted tetrahydroisoquinolines affords pyrrolo[2,1-a]isoquinolines. Scope and limitations of this method are described and an application to the synthesis of the natural product (±)-crispine A is presented. The Royal Society of Chemistry 2013.

A novel pyrrole synthesis

The silver(I)-promoted oxidative cyclization of homopropargylamines at room temperature provides a novel access to pyrroles. Homopropargylamines are readily available by the addition of a propargyl Grignard reagent to Schiff bases.