855749-01-8

Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 288254-64-8 2-(cyclohex-1-en-1-ylethynyl)aniline 
• 615-43-0 2-iodophenylamine 
• 17988-44-2 (cyclohex-1-en-1-ylethynyl)trimethylsilane 
• 17962-22-0 1-((trimethylsilyl)ethynyl)cyclohexanol 
• 108-94-1 cyclohexanone 
• 931-49-7 1-ethenylcyclohexene 
• 61613-20-5 N-tosyl-2-iodoaniline 

Downstream Products

• 855749-08-5 N-(2-(cyclohexenylethynyl)phenyl)-N-ethynyl-4-methylbenzenesulfonamide 
• 855749-20-1 2-(2-(1-cyclohexenyl)ethynyl)-N-(2-(trimethylsilyl)ethynyl)-N-tosylbenzenamine 
• 1415691-18-7 2-(1-cyclohexenyl)-1-tosyl-1H-indole-3-carboxylic acid 
• 910896-40-1 2-phenyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

Metal-free cascade boron–heteroatom addition and alkylation with diazo compounds

Transition metal-catalyzed carbene transfer reaction is one of the most notable advances for C?C bond formation reactionsduring the past decade, which has been widely employed in the preparation of C3-substituted indoles. Here, we described an efficient e

Boron Trichloride-Mediated Synthesis of Indoles via the Aminoboration of Alkynes

We describe an efficient catalyst- and metal-free aminoboration of alkynes to 3-borylated indoles using one of the least expensive boron sources, BCl3. The major dichloro(indolyl)borane products can be used for the in situ construction of usefu

Aminoboration: Addition of B-N ? Bonds across C-C ?€ Bonds

This communication demonstrates the first catalytic aminoboration of C-C π bonds by B-N δ bonds and its application to the synthesis of 3-borylated indoles. The regiochemistry and broad functional group compatibility of this addition reaction enable substitution patterns that are incompatible with major competing technologies. This aminoboration reaction effects the formation of C-B and C-N bonds in a single step from aminoboronic esters, which are simple starting materials available on the gram scale. This reaction generates synthetically valuable N-heterocyclic organoboron compounds as potential building blocks for drug discovery. The working mechanistic hypothesis involves a bifunctional Lewis acid/base catalysis strategy involving the combination of a carbophilic gold cation and a trifluoroacetate anion that activate the C-C π bond and the B-N δ bond simultaneously.

Silver-catalyzed cascade cyclization-stannylation of o-alkynylaniline derivatives with 2-tributylstannylfuran: An efficient synthesis of (3-indolyl)stannanes

A straightforward synthesis of (3-indolyl)stannanes through silver-catalyzed cyclization-stannylation of N-electron-withdrawing group-substituted o-alkynylanilines in the presence of 2-tributylstannylfuran is developed. This method offers several advantages such as no requirement of additional ligands, high efficiency and a wide reaction scope.

Synthesis of carbazoles by dehydro Diels-Alder reactions of ynamides

A new approach to carbazoles and benzannulated carbazoles by means of intramolecular dehydro Diels-Alder of ynamides is reported. N-(o-Ethynyl)aryl ynamides and N-(o-ethynyl) arylynamides were prepared in a few steps starting from o-iodoaniline. Thermal c

Coupling and cycloaddition of ynamides: Homo- and Negishi coupling of tosylynamides and intramolecular [4 + 2] cycloaddition of N-(o-ethynyl)phenyl ynamides and arylynamides

N,N′-aryl- and N,N′-alkyl-buta-1,3-diyne-1,4-ditosylamides have been synthesized for the first time, in good to excellent yields, by copper-catalyzed dimerization of the corresponding N-aryl or N-alkyl tosylynamides. Negishi coupling of N-ethynylzinc tosy

Synthesis of carbazoles from ynamides by intramolecular dehydro Diels-Alder reactions

(Chemical Equation Presented) A new approach to carbazoles and benzannulated carbazoles by means of intramolecular dehydro Diels-Alder reactions of ynamides is reported. By using this approach, carbazoles and benzo[b]-, tetrahydrobenzo[b]-, naphtho[1,2-b]