855836-52-1

Usage

Uses

Used in Organic Synthesis:
3-Bromo-2-iodophenol is utilized as a reagent in organic synthesis for the preparation of pharmaceuticals, agrochemicals, and fine chemicals. Its presence of both bromine and iodine atoms allows for versatile reactions and the creation of a wide range of products.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-Bromo-2-iodophenol is used as a key intermediate for the synthesis of various organic compounds, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
3-Bromo-2-iodophenol is employed as a building block in the agrochemical sector, aiding in the production of compounds that can be used in the development of pesticides and other agricultural chemicals.
Used in Catalytic Reactions:
3-Bromo-2-iodophenol is recognized for its potential application as a substrate in various catalytic reactions within organic chemistry, facilitating the synthesis of complex organic molecules.
Used in Biological Research:
It has been investigated for its potential biological activities, showing promise as a precursor for the synthesis of novel biologically active compounds, which could lead to advancements in medicine and other biological applications.

InChI:InChI=1/C6H4BrIO/c7-4-2-1-3-5(9)6(4)8/h1-3,9H

Upstream product

• 116435-77-9 2-amino-3-bromophenol 
• 863870-79-5 O-3-bromo-2-iodophenyl N,N-diethylcarbamate 
• 450412-22-3 1-bromo-2-iodo-3-methoxybenzene 
• 2398-37-0 3-methoxyphenyl bromide 
• 1369625-72-8 2-[(2-bromophenyl)(diisopropyl)silyl]pyrimidine 
• 1369625-51-3 2-(diisopropyl(phenyl)silyl)pyrimidine 
• 591-50-4 iodobenzene 
• 75-25-2 Bromoform 
• 33948-35-5 2-iodo-cyclopent-2-enone 
• 591-20-8 3-Bromophenol 
• 863870-72-8 O-3-bromophenyl N,N-diethylcarbamate 

Downstream Products

• 14400-94-3 2,3,4,6-tetrabromophenol 
• 863870-93-3 4-bromo-2-butylbenzo[b]furan 
• 450412-22-3 1-bromo-2-iodo-3-methoxybenzene 
• 1287791-68-7 2-(3-bromo-2-iodophenoxy)-2-methylpropanamide 
• 52488-36-5 4-bromo-1H-indole 
• 1244651-60-2 N-[3-bromo-2-(hex-1-yn-1-yl)phenyl]-2-hydroxy-2-methylpropanamide 
• 1244651-64-6 N-(3-bromo-2-(hept-1-ynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-69-1 N-(3-bromo-2-(2-(trimethylsilyl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244651-72-6 N-(3-bromo-2-(2-(thiophen-3-yl)ethynyl)phenyl)-2-hydroxy-2-methylpropanamide 
• 1244652-11-6 4-bromo-2-(3-chlorophenyl)-1H-indole 
• 1244651-37-3 N-(3-bromo-2-iodophenyl)-2-hydroxy-2-methylpropanamide 
• 1287792-00-0 2-phenyl-4-(2-phenylethynyl)-1H-indole 
• 1287792-08-8 4-bromo-2-butyl-3-(phenylthio)-1H-indole 
• 1287792-10-2 2-butyl-4-phenyl-1H-indole 

Relevant academic research and scientific papers

An Efficient and Modular Route to C 3?-TunePhos-Type Ligands

An efficient and modular synthetic route to the bidentate C 3?-TunePhos was developed, which allowed tunable steric and electronic effects of the ligands. This novel chemical technology highlights a versatile C 3?-dibromodiphenyl int

Synthesis of Polysubstituted Meta-Halophenols by Anion-Accelerated 2π-Electrocyclic Ring Opening

Disrotatory – thermally allowed – 2π-electrocyclic ring-opening reactions require high temperatures to proceed. Herein, we report the first anion-accelerated 2π-electrocyclic ring opening of 6,6-dihalobicyclo[3.1.0]hexan-2-ones at low temperature to give the corresponding meta-halophenols in good to high yields (18 examples, 29–92 % yield, average: 65 %). Many of the phenols have unconventional substitution patterns and are reported here for the first time. Furthermore, the strength of the methodology was shown by the total synthesis of the densely functionalized phenolic natural product caramboxin (isolated as the lactam dehydrate). The reaction mechanism underlying the anion-acceleration was investigated in an ab initio study, which concluded that base-mediated proton abstraction anti to the concurrently departing endo-bromine was the initiating step in an overall concerted reaction mechanism leading directly to the meta-halophenol.

Twofold unsymmetrical C-H functionalization of PyrDipSi-substituted arenes: A general method for the synthesis of substituted meta-halophenols

And the world is your oyster Sequential halogenation/oxygenation reactions of 2-diisopropylsilylpyrimidine-substituted arenes provide a general and efficient synthesis of substituted meta-halophenols from simple aryl iodides (see scheme; Piv=pivaloyl). The products are poised to undergo diverse C-C, C-N, and C-O bond-forming reactions that enable the transformation of their framework and the introduction of valuable functionalities. Copyright

Approaches to the synthesis of 2,3-dihaloanilines. Useful precursors of 4-functionalized-1 H-indoles

2,3-Dihaloanilines have been proved as useful starting materials for synthesizing 4-halo-1H-indoles. Subsequent or in situ functionalization of the prepared haloindoles allows the access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles in good overall yields. As no efficient synthetic routes to 2,3-dihaloanilines have been described in the literature, different approaches to the preparation of these 1,2,3-functionalized aromatic precursors are now presented. The most general one involves a Smiles rearrangement from the corresponding 2,3-dihalophenols and allows the preparation of 2,3-dihaloanilides in a straightforward and synthetically useful manner.

Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.

Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: Application to the preparation of indole inhibitors of phospholipase A 2

(Chemical Equation Presented) An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole. Directed ortho-metalation followed by two pallad

A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols

Tandem Sonogashira coupling/5-endo-dig cyclization reactions on 2,3-dihalophenols suppose a straightforward entry to 4-halobenzo[b]furans, which can be easily transformed into 4-functionalized benzo[b]furans, that are difficult to synthesize by other proc