450412-22-3

Basic information

• Product Name: 1-Bromo-2-iodo-3-methoxybenzene
• Synonyms: 1-Bromo-2-iodo-3-methoxybenzene;1-Bromo-2-iodo-3-methoxybenzene, 3-Bromo-2-iodophenyl methyl ether
• CAS NO: 450412-22-3
• Molecular Formula: C₇H₆BrIO
• Molecular Weight: 312.93041
• Mol File: 450412-22-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 63-65 °C
• Boiling Point: 287.1±25.0 °C(Predicted)
• Appearance: /
• Density: 2.062±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 1-Bromo-2-iodo-3-methoxybenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Bromo-2-iodo-3-methoxybenzene(450412-22-3)
• EPA Substance Registry System: 1-Bromo-2-iodo-3-methoxybenzene(450412-22-3)

Safety Data

• Hazardous Substances Data: 450412-22-3(Hazardous Substances Data)

Usage

General Description

1-Bromo-2-iodo-3-methoxybenzene is a chemical compound with the molecular formula C7H5BrIO2. 1-Bromo-2-iodo-3-methoxybenzene is part of the halomethanes chemical group, which are organic compounds containing at least one halogen atom along with a carbon atom. It's essentially an aromatic ether that has been predominantly used in the field of organic synthesis. Being relatively heavy and having a polar characteristic, this aromatic compound is typically solid at room temperature. It’s a very specific type of organobromide and organoiodide. Its systematic name is 1-bromo-2-iodo-3-methoxybenzene indicating the position of bromine, iodine and methoxy group in the benzene ring. It's not naturally occurring and has to be synthesized in the lab with proper precautions due to its potential reactive nature.

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 855836-52-1 3-bromo-2-iodophenol 
• 74-88-4 methyl iodide 
• 863870-79-5 O-3-bromo-2-iodophenyl N,N-diethylcarbamate 
• 863870-72-8 O-3-bromophenyl N,N-diethylcarbamate 

Downstream Products

• 945470-14-4 1-bromo-3-methoxy-2-phenylethynylbenzene 
• 1006715-21-4 2-allyl-3-(dimethylphenylsilyl)-anisole 
• 1006715-18-9 (3-methoxyphenyl)dimethyl(phenyl)silane 
• 855836-52-1 3-bromo-2-iodophenol 
• 352525-79-2 C₇H₈BBrO₃ 
• 1595078-07-1 (2-bromo-6-methoxyphenyl)boronic acid pinacol ester 
• 325142-84-5 3-methoxyphenylboronic acid pinacol ester 
• 1421187-17-8 1-bromo-3-methoxy-2-((2-methoxy-6-methylphenyl)ethynyl)benzene 
• 1421187-14-5 1-((2-bromo-6-methoxyphenyl)ethynyl)-2-methoxynaphthalene 
• 1421187-10-1 1-((2-bromo-6-methoxyphenyl)ethynyl)-2-methylnaphthalene 
• 1332533-02-4 4-methoxy-3-(methylthio)-2-phenylbenzo[b]thiophene 
• 1332532-69-0 1-bromo-2-(hept-1-ynyl)-3-methoxybenzene 
• 1287791-68-7 2-(3-bromo-2-iodophenoxy)-2-methylpropanamide 
• 1287792-10-2 2-butyl-4-phenyl-1H-indole 

Relevant articles and documents

Combined directed ortho-zincation and palladiumcatalyzed strategies: Synthesis of 4,n-dimethoxysubstituted benzo[b]furans

A new route to regioselectively dialkoxy-functionalized benzo[b]furan derivatives has been developed from 3-halo-2-iodoanisoles bearing an additional methoxy group, which have been accessed through an ortho-zincation/iodination reaction. Two palladiumcata

Synthesis of 4-functionalized-1H-indoles from 2,3-dihalophenols

A new synthesis of 4-halo-1H-indoles has been developed from easily available 2,3-dihalophenol derivatives. The key steps are Smiles rearrangement and a one-pot or stepwise Sonogashira coupling/NaOH-mediated cyclization. Subsequent functionalization allows access to a wide variety of 2,4- or 2,3,4-regioselectively functionalized indoles.

Regioselective synthesis of 4- and 7-alkoxyindoles from 2,3-dihalophenols: Application to the preparation of indole inhibitors of phospholipase A 2

(Chemical Equation Presented) An efficient and regioselective synthesis of 4- and 7-alkoxyindoles has been developed from commercially available starting materials such as 3-halophenols and 3-chloroanisole. Directed ortho-metalation followed by two pallad