85648-10-8

Usage

Category

Chiral alcohols

Use

Intermediate in the synthesis of pharmaceuticals and other organic compounds

Chiral nature

Has a non-superposable mirror image

(S)-enantiomer

Utilized in the pharmaceutical industry for the production of various drugs and active pharmaceutical ingredients

Molecular structure

Unique and versatile for the synthesis of biologically active compounds

Upstream product

• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 85613-46-3 2-Phenyl-3-cyclopropyl-5-(hydroxymethyl)-oxazolidine 
• 120182-60-7 (4S)-2,2-dimethyl-4[[2-(3,4-dimethoxyphenyl)ethylamino]methyl]-1,3-dioxolane 

Downstream Products

• 66781-20-2 (S) 2-phenyl-3-[2-(3,4-dimethoxyphenyl)ethyl]-5-hydroxymethyloxazolidine 
• 85613-47-4 (S)-2-phenyl-3-<2-(3,4-dimethoxyphenyl)ethyl>-5-(hydroxymethyl)oxazolidine p-toluenesulfonate 
• 85648-13-1 (S)-2-amino>-2-hydroxypropoxy>phenyl>-4-(2-thienyl)imidazole 
• 85613-42-9 (S)-4-<3-<<2-(3,4-dimethoxyphenyl)ethyl>amino>-2-hydroxypropoxy>benzaldehyde 
• 66781-20-2 {(S)-3-[2-(3,4-Dimethoxy-phenyl)-ethyl]-2-phenyl-oxazolidin-5-yl}-methanol 

Relevant academic research and scientific papers

Process for preparing alkoxyalkylidenehydrazinopyridazine derivatives

A novel process for preparing alkoxyalkylidenehydrazinopyridazine derivatives which comprises reducing a novel alkoxytriphenylmethylazopyridazine derivative, removing the triphenylmethyl group and reacting with an aldehyde or ketone derivative. A specific

Process for preparing alkoxyalkyl-idenehydrazinopyridazine derivatives

A process for preparing a compound of the formula (4): is described wherein R3 and R4 are both hydrogen or together are =CR1R2, where R1 is hydrogen or C1-3alkyl and R2 is C1-3alkyl, carboxy or phenyl,which comprises reduc

BETA-ADRENERGIC BLOCKING IMIDAZOLYLPHENOXY PROPANOLAMINES

Substituted imidazoles and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity. STR1

3-AMINO-2-HYDROXYPROPOXYARYL IMIDAZOLE DERIVATIVES

Novel substituted imidazoles of the formula STR1 and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and β-adrenergic blocking activity.

β1-Selective adrenoceptor antagonists: Examples of the 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazole class

A series of 2-[4-[3-(substituted-amino)-2-hydroxypropoxy]phenyl]imidazoles is described. The compounds were investigated in vitro for β-adrenoceptor antagonism, and several examples were found to be selective for the β1-adrenoceptor. The structure-activity relationship exhibited by this series of compounds is discussed. (S)-2-[p-[3-[[2-(3,4-dimethoxyphenyl)ethyl]amino]-2-hydroxypropoxy]phenyl] -4-(2-thienyl)imidazole [(S)-13] was over 100 times more selective than atenolol for the β1-adrenergic receptor and has been selected for in-depth studies.