856409-63-7

Upstream product

• 161374-29-4 N-allyl-N-but-2-ynyl-4-methyl-benzenesulfonamide 
• 876069-79-3 N-(but-2-ynyl)-N-(2,2-dimethoxyethyl)-4-methylbenzenesulfonamide 
• 2645-02-5 methyl tosylglycinate 
• 14316-14-4 N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 58754-95-3 N-(2,2-dimethoxyethyl)-p-toluenesulfonamide 

Downstream Products

• 1173788-48-1 N-but-2-ynyl-N-(2-hydroxypropyl)-4-methylbenzenesulfon-amide 

Relevant academic research and scientific papers

Ni-Catalyzed Cyclization of Enynes and Alkynylboronates: Atom-Economical Synthesis of Boryl-1,4-dienes

We report a novel atom-economical Ni-catalyzed cyclization reaction of enynes with alkynylboronates. The reaction employs a non-expensive Ni salt, a phosphine-based ligand and easy-handling alkynylboronates as boron–carbon source. The reaction provides co

Thiyl radical-mediated cyclization of ω-alkynyl O-tert-butyldiphenylsilyloximes

ω-Alkynyl O-tert-butyldiphenylsilyloximes, upon treatment with odorless 4-tert-butylbenzenethiol in the presence of azobisisobutyronitrile (AIBN) in refluxing benzene, underwent addition of a thiyl radical to the alkynyl group followed by radical cyclizat

Gold-catalyzed intramolecular regio- and enantioselective cycloisomerization of 1,1-bis(indolyl)-5-alkynes

Bis(indole) alkaloids analogues were prepared under mild conditions and in high yields through a gold-catalyzed cycloisomerization of 1,1-bis(indolyl)-5- alkynes (see scheme). The enan Copyright

Cationic rhodium(I)/H8-binap complex catalyzed [2+2+2] cycloadditions of 1,6- And 1,7-diynes with carbonyl compounds

We have established that a cationic rhodium(I)/H8-binap complex catalyzes [2+2+2] cycloadditions of a variety of 1,6and 1,7-diynes with both electron-deficient and electron-rich carbonyl compounds, leading to dienones in high yield under mild reaction conditions. In the reactions with acyl phosphonates, the reactivity of 1,6- and 1,7-diynes was highly dependent on their own structures. The addition of chelating diethyl oxalate effectively promoted the [2+2+2] cycloadditions involving acyl phosphonates, presumably due to the equilibrium formation of the desired 1:1 rhodium complex of the diyne and the acyl phosphonate by facile ligand exchange between the diyne and weakly coordinated diethyl oxalate. In the reactions involving bifunctional carbonyl compounds or unsymmetrical 1,6-diynes, high chemo- or regioselectivities were observed. Wiley-VCH Verlag GmbH & Co. KGaA.

Palladium(0)-catalyzed alkylative cyclization of alkynals and alkynones: Remarkable trans-addition of organoboronic reagents

Palladium/monophosphine complexes catalyze trans-selective arylative, alkenylative, and alkylative cyclization reactions of alkynals and alkynones with organoboronic reagents. These reactions afford six-membered allylic alcohols with endo-tri- or tetrasub

Mercuric chloride and iodide mediated cyclization of tethered alkynedithioacetals as a general route to five- and six-membered rings: Tuning of regioselectivity by alkyne substitution

Mercuric chloride mediated cyclization of tethered alkynedithioacetals has been established as a general route to five- and six-membered carbocycles and heterocycles. Substitution at the alkyne terminus leads to preferential formation of five-membered rings, whereas unsubstituted alkynedithioacetals give six-membered rings as the major products. Mercuric iodide interrupts the reaction at the intermediate dithioacetal stage.

Alkynes as synthetic equivalents to stabilized wittig reagents: Intra- and intermolecular carbonyl olefinations catalyzed by Ag(I), BF3, and HBF4

(Chemical Equation Presented) The first use of cationic silver (AgSbF 4) as a catalyst for intra- and intermolecular alkyne - carbonyl coupling to form conjugated enones is described, and a comparison to corresponding Bronsted acid (HBF4/