85658-60-2Relevant academic research and scientific papers
Heterocyclic Rearrangements. Synthesis of 1,2,4-Oxadiazolopyrimidinium Systems and Their Ring Opening into Pyrimidine N-Oxides
Buscemi, Silvestre,Macaluso, Gabriella,Frenna, Vincenzo,Vivona, Nicolo
, p. 1175 - 1177 (2007/10/02)
The reaction of 3-amino-5-phenyl-(methyl)-1,2,4-oxadiazole with acetylacetone or benzoylacetone in the presence of perchloric acid has been studied.Synthesis of 1,2,4-oxadiazolopyrimidinium perchlorates and their ring opening reaction into aminopyrimidine N-oxides is reported.
Heterocyclic Rearrangements: Rearrangement of N-(1,2,4-Oxadiazol-3-yl)-β-enamino Ketones into Pyrimidine N-Oxides
Vivona, Nicolo,Buscemi, Silvestre,Frenna, Vincenzo,Ruccia, Michele
, p. 17 - 20 (2007/10/02)
The behaviour of N-(5-R-1,2,4-oxadiazol-3-yl)-β-enamino ketones towards rearrangement has been investigated.In the presence of anionic reagents in ethanol solution, they rearrange to pyrimidine N-oxides.The synthesis and hydrolytic ring opening of a oxadiazolopyrimidinium system is also reported.
Transformations of 2-Aminopyrimidines and Their N-Oxides under Diazotation Conditions
Sedova, V. F.,Mustafina, T. Yu.,Krivopalov, V. P.,Mamaev, V. P.
, p. 91 - 94 (2007/10/02)
The diazotation of 2-aminopyrimidines and their N-oxides in solutions with various acidities was studied.It is shown that the amino group in pyrimidine N-oxides is not diazotized in strongly acidic media and that bromination in the 5 position of the pyrimidine ring is observed in concentrated hydrobromic acid.When the reaction was carried out in moderately acidic media, it was possible to synthesize the difficult-to-obtain 2-halopyrimidine N-oxides.
