856806-80-9

Upstream product

• 67-56-1 methanol 
• 118-45-6 4-chlorophthalic anhydride 
• 90072-77-8 4-nitro-phthalic acid-1-methyl ester 
• 124-41-4 sodium methylate 
• 58138-38-8 dimethyl 4-chlorophthalate 

Downstream Products

• 583835-18-1 6-bromo-2-(4-methanesulfonylbenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carbaldehyde 
• 109702-73-0 4-Chloro-2-(2-diazo-acetyl)-benzoic acid methyl ester 
• 1029972-01-7 4chloro-2-chlorocarbonylbenzoic acid methyl ester 

Relevant academic research and scientific papers

Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)

A novel series of 4-phenylisoquinolones were synthesized and evaluated as c-Jun N-terminal kinase (JNK) inhibitors. Initial modification at the 2- and 3-positions of the isoquinolone ring of hit compound 4, identified from high-throughput screening, led to the lead compound 6b. The optimization was carried out using a JNK1-binding model of 6b and several compounds exhibited potent JNK inhibition. Among them, 11g significantly inhibited cardiac hypertrophy in rat pressure-overload models without affecting blood pressure and the concept of JNK inhibitors as novel therapeutic agents for heart failure was confirmed.

JNK INHIBITOR

A JNK inhibitor containing a compound having an isoquinolinone skeleton or a salt thereof, such as a compound represented by the formula wherein ring A and ring B are each an optionally substituted benzene ring, X is -O-, -N=, -NR3- or -CHR3-, R2 is an acyl group, an optionally esterified or thioesterified carboxyl group, an optionally substituted carbamoyl group or an optionally substituted amino group and the like, a broken line shows a single bond or a double bond, and R1 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group and the like, and the like.