856836-44-7

Usage

Uses

Used in Pharmaceutical Development:
3-Chloro-6-methoxypyridine-2-carboxylic acid is used as a key intermediate in the synthesis of various biologically active compounds for pharmaceutical applications. Its presence of chloro and methoxy groups allows for the development of new drugs with potential therapeutic effects.
Used in Agrochemical Production:
In the agrochemical industry, 3-Chloro-6-methoxypyridine-2-carboxylic acid is utilized as a starting material for the creation of novel agrochemicals, contributing to the advancement of crop protection and pest control agents.
Used in Fine Chemicals Synthesis:
3-Chloro-6-methoxypyridine-2-carboxylic acid is employed as a valuable precursor in the production of a wide range of fine chemicals, including specialty chemicals and advanced materials, due to its versatile chemical reactivity and structural features.

InChI:InChI=1/C8H8ClNO3/c1-12-6-4-3-5(9)7(10-6)8(11)13-2/h3-4H,1-2H3

Upstream product

• 856835-28-4 3-(acetylamino)-6-methoxypyridine-2-carboxylic acid 
• 67-56-1 methanol 
• 1702-17-6 Clopyralid 
• 124-41-4 sodium methylate 
• 52090-65-0 N-(6-methoxy-2-methyl-3-pyridyl)acetamide 

Downstream Products

• 68160-46-3 3-chloro-6-hydroxypicolinic acid 
• 1257535-51-5 C₇H₅Cl₂NO₂ 
• 859302-39-9 3-p-anisidino-6-methoxy-pyridine-2-carboxylic acid 

Relevant academic research and scientific papers

DIHYDROOROTATE DEHYDROGENASE INHIBITORS

Disclosed are compounds, compositions and methods for treating diseases, disorders, or medical conditions that are affected by the modulation of DHODH. Such compounds are represented by Formula (I) as follows: wherein R1a, R1b, R2, and R3, are defined herein.

Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist

Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the pharmacological properties of this lead. Initial efforts investigated a series of heteroaromatic bioisosteres, which demonstrated improved physicochemical properties but reduced P2X7R antagonism. Installation of bioisosteric fluorine on the adamantane bridgeheads was well tolerated and led to a series of bioisosteres with improved physicochemical properties and metabolic stability. Trifluorinated benzamide 34 demonstrated optimal physicochemical parameters, superior metabolic stability (ten times longer than lead benzamide 1), and an improved physicokinetic profile and proved effective in the presence of several known P2X7R polymorphisms.

Heteroarylaminopyrazole derivatives useful for the treatment of diabetes

The present invention relates to heteroarylaminopyrazole compounds, pharmaceutical compositions, and methods for treating diabetes and related disorders.