85729-24-4Relevant academic research and scientific papers
Rapid access to N-(indol-2-yl)amides and N-(indol-3-yl)amides as unexplored pharmacophores
Reekie, Tristan A.,Wilkinson, Shane M.,Law, Vivian,Hibbs, David E.,Ong, Jennifer A.,Kassiou, Michael
, p. 576 - 580 (2017/01/25)
Preparation of N-(indol-2-yl)amides and N-(indol-3-yl)amides are scarce in the scientific literature due to unstable intermediates impeding current reported syntheses. We have employed cheap and readily available substrates in the Curtius rearrangement of
Efficient reductive acylation of 3-nitroindoles
Roy, Sujata,Roy, Sudipta,Gribble, Gordon W.
, p. 1531 - 1533 (2008/09/19)
3-Nitroindoles are catalytically reduced by hydrogen on palladium/carbon to furnish the relatively unstable aminoindoles, which in the presence of carboxylic acid anhydrides afford good to excellent yields of the corresponding N-acylaminoindoles. 2-Nitroi
Convenient synthesis of masked aminoindoles by indium mediated one-pot reductive acylation of 3- and 2-nitroindoles
Roy, Sujata,Gribble, Gordon W.
, p. 51 - 56 (2007/10/03)
Unstable 3- and 2-aminoindoles arc generated in situ by indium mediated reduction of 3- and 2-nitroindoles and capped as the stable amides (or carbamate) in moderate to high yields under mild conditions in a one-pot procedure.
