19012-01-2

Basic information

• Product Name: 3-Benzoyl-1-methyl-1H-indole
• Synonyms: 3-Benzoyl-1-methyl-1H-indole;(1-Methyl-1H-indol-3-yl)phenylmethanone;3-Benzoyl-1-methylindole;3-Benzoyl-N-methylindole
• CAS NO: 19012-01-2
• Molecular Formula: C₁₆H₁₃NO
• Molecular Weight: 0
• Mol File: 19012-01-2.mol
• Article Data: 40

Chemical Properties

• Melting Point: 117℃
• Appearance: /
• Density: 1.11
• CAS DataBase Reference: 3-Benzoyl-1-methyl-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Benzoyl-1-methyl-1H-indole(19012-01-2)
• EPA Substance Registry System: 3-Benzoyl-1-methyl-1H-indole(19012-01-2)

Safety Data

• Hazardous Substances Data: 19012-01-2(Hazardous Substances Data)

Upstream product

• 15224-25-6 3-benzoylindole 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 111123-02-5 1-Methyl-3-(2-phenyl-benzo[1,3]oxathiol-2-yl)-1H-indole 
• 960-16-7 tributylphenylstannane 
• 16382-38-0 1-methylindole-3-glyoxylyl chloride 
• 603-76-9 1-methylindole 
• 201230-82-2 carbon monoxide 
• 98-80-6 phenylboronic acid 
• 24388-23-6 2-phenyl-4,4,5,5-tetramethyl-1,3,2-dioxoborole 
• 85092-84-8 3-iodo-1-methyl-1H-indole 
• 611-73-4 Benzoylformic acid 
• 74-83-9 methyl bromide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 112122-42-6 1-(1-Methylindol-3-yl)-1-phenyl-ethen 
• 1908-67-4 (1-methyl-1H-indol-3-yl)(phenyl)methanol 
• 3265-24-5 (E)-3-(hydroxyimino)-1-methylindolin-2-one 
• 85729-24-4 N-(1-methyl-1H-indol-3-yl)benzamide 
• 82414-24-2 3-benzoyl-1-methylindole, Z-oxime 
• 82414-24-2 3-benzoyl-1-methylindole, E-oxime 
• 82414-31-1 1-methyl-1H-indole-3-carboxylic acid phenylamide 
• 29670-54-0 3,3'-(phenylmethane-1,1-diyl)bis(1-methyl-1H-indole) 
• 100-52-7 benzaldehyde 
• 1392145-12-8 C₂₉H₂₅NO 
• 1392145-14-0 C₂₉H₂₅NO 
• 26821-93-2 (1-methyl-2-phenyl-1H-indol-3-yl)(phenyl)methanone 
• 1410876-49-1 C₃₇H₂₈N₂O 
• 1410877-17-6 1-(1-methyl-1H-indol-3-yl)-1,3-diphenylprop-2-yn-1-ol 

Relevant articles and documents

Palladium-Catalyzed 2-fold C-H Activation/C-C Coupling for C4-Arylation of Indoles Using Weak Chelation

Palladium-catalyzed weak chelation-assisted regioselective C4-arylation of indoles has been accomplished using a readily available arene at moderate temperature. The C4-arylation, weak chelating benzoyl (Bz) directing group, cross-dehydrogenative coupling (CDC), broad substrate scope, and late-stage diversifications are the important practical features.

Electrochemically Enabled C3-Formylation and -Acylation of Indoles with Aldehydes

Reported herein is an effective strategy for oxidative cross-coupling of indoles with various aldehydes. The strategy is based on a two-step transformation via a well-known Mannich-type reaction and a C-N bond cleavage for carbonyl introduction. The key step - the C-N bond cleavage of the Mannich product - was enabled by electrochemistry. This strategy (with over 40 examples) ensures excellent functional-group tolerance as well as late-stage functionalization of pharmaceutical molecules.

Iridium- and Rhodium-Catalyzed Directed C-H Heteroarylation of Benzaldehydes with Benziodoxolone Hypervalent Iodine Reagents

The C-H heteroarylation of benzaldehydes with indoles and pyrroles was realized using the benziodoxolone hypervalent iodine reagents indole- and pyrroleBX. Functionalization of the aldehyde C-H bond using either an o-hydroxy or amino directing group and catalyzed by an iridium or a rhodium complex allowed the synthesis of salicyloylindoles and (2-sulfonamino)benzoylindoles, respectively, with good to excellent yields (74-98%). This new transformation could be carried out under mild conditions (rt to 40 °C) and tolerated a broad range of functionalities, such as ethers, halogens, carbonyls, or nitro groups.