857532-13-9

Basic information

• Product Name: BenzeneMethanol, α-(aMinoMethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-
• Synonyms: BenzeneMethanol, α-(aMinoMethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-;2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)phenyl]ethanol
• CAS NO: 857532-13-9
• Molecular Formula: C₁₇H₁₆ClN₃O
• Molecular Weight: 313.78144
• Mol File: 857532-13-9.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BenzeneMethanol, α-(aMinoMethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-(CAS DataBase Reference)
• NIST Chemistry Reference: BenzeneMethanol, α-(aMinoMethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-(857532-13-9)
• EPA Substance Registry System: BenzeneMethanol, α-(aMinoMethyl)-α-(4-chlorophenyl)-4-(1H-pyrazol-4-yl)-(857532-13-9)

Safety Data

• Hazardous Substances Data: 857532-13-9(Hazardous Substances Data)

Upstream product

• 99847-42-4 (4-chlorophenyl)(4-iodophenyl)methanone 
• 1056901-63-3 [2-(4-chloro-phenyl)-2-hydroxy-2-(4-iodo-phenyl)ethyl]-carbamic acid tert-butyl ester 
• 917899-14-0 2-amino-1-(4-chloro-phenyl)-1-(4-iodo-phenyl)-ethanol 
• 857532-00-4 (RS)-2-(4-chloro-phenyl)-2-(4-iodo-phenyl)-oxirane 
• 1056901-64-4 2-(4-chloro-phenyl)-2-hydroxy-2-[4-(1H-pyrazol-4-yl)-phenyl]-ethyl-carbamic acid tert-butyl ester 

Relevant articles and documents

PHARMACEUTICAL COMBINATIONS COMPRISING PYRAZOLE DERIVATIVES AS PROTEIN KINASE MODULATORS

The invention provides a combination comprising an ancillary compound (e.g. one, two or more ancillary compounds) and a compound of the formula (I) having protein kinase B inhibiting activity: wherein A is a saturated hydrocarbon linker group containing f

PHARMACEUTICAL COMPOUNDS

The invention provides a composition comprising (S) 2-amino-1-(4-chloro-phenyl)- 1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)- phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S) 2-amino-1-(4-chloro-phenyl)-1-[4-(1H- pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.

PHARMACEUTICAL COMPOUNDS

The invention provides compounds of the formula (I) having ROCK kinase and/or protein kinase p70S6K inhibiting activity: wherein A is a saturated hydrocarbon linker group containing from 1 to 7 carbon atoms, the linker group having a maximum chain length