857680-63-8

Usage

Chemical compound

2,8-Diazaspiro[4.5]decan-1-one, 4-(4-fluorophenyl)-

Structure

Spirocyclic with a diazaspirodecane ring

Substituent

4-(4-fluorophenyl) attached to the spirocyclic ring

Properties

Potential pharmaceutical properties

Applications

Used in the development of new drugs or as a building block for the synthesis of other organic compounds

Biological activities

The presence of the fluorophenyl group could impart specific biological or pharmacological activities to the molecule

Interest

Suitable for further research and medicinal chemistry applications.

Upstream product

• 857681-22-2 rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 857680-64-9 rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 876592-60-8 rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester 
• 857680-66-1 rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 

Downstream Products

• 857873-69-9 rac-4-(4-Fluoro-phenyl)-8-(2-hydroxy-cyclohexyl)-2,8-diaza-spiro[4.5]decan-1-one 
• 857680-68-3 (S)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one 
• 857680-67-2 (R)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one 
• 857680-66-1 rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

ISOFORM SELECTIVE PHOSPHOLIPASE D INHIBITORS

Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Diaza-spiropiperidine derivatives

The present invention relates to compounds of formula wherein A—B, R1, R2, R3, R4, and n are as defined herein; and to pharmaceutically acceptable salts thereof. The compounds of formula I may be used in the tre

A straightforward and efficiently scaleable synthesis of novel racemic 4-substituted-2,8-diazaspiro[4.5]decan-1-one derivatives

Novel and straightforward syntheses (3-5 steps, high yields) of racemic diazaspiropiperidine derivatives based on the Michael addition of pipecolate-derived enolates to a range of nitroalkenes have been developed. The reaction has been shown to have a gen

Diaza-spiropiperidine derivatives

The present invention relates to compounds of formula wherein A-B is —CH2—CH2—, —CH2—O— or —O—CH2—; X is hydrogen or hydroxy; R1 is aryl, optionally substituted by one or two substituents selected fro