857680-67-2

Upstream product

• 857680-66-1 rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 857681-22-2 rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride 
• 857680-63-8 rac-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 
• 1126-09-6 4-carbethoxypiperidine 
• 857680-64-9 rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester 
• 876592-60-8 rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester 

Downstream Products

• 1262537-04-1 tert-butyl (S)-1-((R)-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)propan-2-ylcarbamate 
• 857680-69-4 (R)-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one 1R-(-)-camphorsulfonate 

Relevant academic research and scientific papers

Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives

This letter describes the on-going SAR efforts to develop PLD1, PLD2 and dual PLD1/2 inhibitors with improved physiochemical and disposition properties as well as securing intellectual property position. Previous PLD inhibitors, based on a triazaspiro[4.5

ISOFORM SELECTIVE PHOSPHOLIPASE D INHIBITORS

Disclosed are isoform selective Phospholipase D inhibitors. In one aspect, the disclosed compounds can have a structure represented by a formula (I): Also disclosed are methods of making and using the compounds. Also disclosed are pharmaceutical compositions and kits comprising the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

A straightforward and efficiently scaleable synthesis of novel racemic 4-substituted-2,8-diazaspiro[4.5]decan-1-one derivatives

Novel and straightforward syntheses (3-5 steps, high yields) of racemic diazaspiropiperidine derivatives based on the Michael addition of pipecolate-derived enolates to a range of nitroalkenes have been developed. The reaction has been shown to have a gen

Diaza-spiropiperidine derivatives

The present invention relates to compounds of formula wherein A—B, R1, R2, R3, R4, and n are as defined herein; and to pharmaceutically acceptable salts thereof. The compounds of formula I may be used in the tre