857680-64-9

Basic information

• Product Name: rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
• Synonyms: rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester
• CAS NO: 857680-64-9
• Molecular Weight: 424.469
• Mol File: 857680-64-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester(857680-64-9)
• EPA Substance Registry System: rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester(857680-64-9)

Safety Data

• Hazardous Substances Data: 857680-64-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 1126-09-6 4-carbethoxypiperidine 
• 706-08-1 trans-1-(4-fluorophenyl)-2-nitro-ethene 
• 142851-03-4 1-tert-butyl 4-ethyl piperidine-1,4-dicarboxylate 

Downstream Products

• 857680-66-1 rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester 
• 857680-68-3 (S)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one 
• 857680-67-2 (R)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one 
• 857680-63-8 rac-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one 
• 876592-60-8 rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester 

Relevant articles and documents

Isoform selective PLD inhibition by novel, chiral 2,8-diazaspiro[4.5]decan-1-one derivatives

This letter describes the on-going SAR efforts to develop PLD1, PLD2 and dual PLD1/2 inhibitors with improved physiochemical and disposition properties as well as securing intellectual property position. Previous PLD inhibitors, based on a triazaspiro[4.5

Diaza-spiropiperidine derivatives

The present invention relates to compounds of formula wherein A—B, R1, R2, R3, R4, and n are as defined herein; and to pharmaceutically acceptable salts thereof. The compounds of formula I may be used in the tre