857775-99-6Relevant academic research and scientific papers
Mild and efficient synthesis of indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction
Weng, Wei-Zhi,Xie, Jian,Zhang, Bo
supporting information, p. 3983 - 3988 (2018/06/08)
A simple and efficient approach for the preparation of substituted indoles and isoquinolones via a nickel-catalyzed Larock-type heteroannulation reaction is reported. This transformation employed air-stable and inexpensive Ni(dppp)Cl2 as a precatalyst and Et3N as a mild base. Moreover, the reaction occurs efficiently under mild conditions, and a wide range of substituted indoles and isoquinolones bearing various functional groups are obtained in moderate to excellent yields.
Mechanochemical indole synthesis by rhodium-catalysed oxidative coupling of acetanilides and alkynes under solventless conditions in a ball mill
Hermann, Gary N.,Jung, Celine L.,Bolm, Carsten
supporting information, p. 2520 - 2523 (2017/07/17)
A mechanochemical indole synthesis by rhodium(iii)-catalysed C-H bond functionalisation in a planetary mill has been developed. It occurs in the absence of any solvent, does not require additional heating and only needs catalytic quantities of Cu(OAc)2 in combination with dioxygen as a terminal oxidant. Accordingly, the process represents a powerful and environmentally benign alternative to the common solution-based standard protocols.
Synthesis of indoles and polycyclic amides via ruthenium(ii)-catalyzed C-H activation and annulation
Lin, Hui,Li, Shuai-Shuai,Dong, Lin
supporting information, p. 11228 - 11234 (2015/11/27)
Ruthenium(ii)-catalyzed oxidative coupling of NH protic amides with alkynes has been developed for the synthesis of a diversity of complex structures, such as N-acyl indole and tricyclic amide derivatives.
Oxidative annulation of anilides with internal alkynes using an (Electron-Deficient η5-cyclopentadienyl)rhodium(III) catalyst under ambient conditions
Hoshino, Yuki,Shibata, Yu,Tanaka, Ken
, p. 1577 - 1585 (2014/06/09)
A dinuclear (electron-deficient η5-cyclopentadienyl) rhodium(III) complex was synthesized on a preparative scale via the rhodium-catalyzed cross [2+2+1] cyclotrimerization of silylacetylenes and two alkynyl esters, leading to substituted silylf
Synthesis of indoles via palladium-catalyzed C-H activation of N-aryl amides followed by coupling with alkynes
Zhou, Feng,Han, Xiuling,Lu, Xiyan
supporting information; experimental part, p. 4681 - 4685 (2011/09/30)
A convenient and efficient method for the construction of indole skeleton was developed via Pd-catalyzed C-H activation of N-aryl amides and subsequent coupling with alkynes. Both stoichiometric and catalytic versions have been successfully achieved.
