168640-82-2

Basic information

• Product Name: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol
• Synonyms: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol;Azido-PEG4-Tos;2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;11-Azido-3,6,9-trioxaundecanyl p-toluenesulfonate;N3-PEG4-Tos
• CAS NO: 168640-82-2
• Molecular Formula: C₁₅H₂₃N₃O₆S
• Molecular Weight: 0
• Mol File: 168640-82-2.mol
• Article Data: 38

Chemical Properties

• Appearance: /
• Solubility: Soluble in DMSO, DCM, DMF
• CAS DataBase Reference: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(168640-82-2)
• EPA Substance Registry System: 2-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]-1-(p-toluenesulfonyl)-ethanol(168640-82-2)

Safety Data

• Hazardous Substances Data: 168640-82-2(Hazardous Substances Data)

Usage

Description

Azide-PEG4-Tos is a heterofunctional crosslinker containing an azide (N3) group and a tosyl group. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The tosyl group is a good leaving group for nucleophilic substitution reactions. PEG spacer increases solubility in aqueous media.

Upstream product

• 112-60-7 Tetraethylene glycol 
• 98-59-9 p-toluenesulfonyl chloride 
• 41024-91-3 penta(ethylene glycol) bis(p-toluenesulfonate) 
• 77544-60-6 p-toluenesulfonic acid 2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethyl ester 
• 86770-67-4 2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethanol 
• 37860-51-8 tetraethylene glycol di(p-toluenesulfonate) 

Downstream Products

• 1151451-77-2 4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)benzaldehyde 
• 1262209-98-2 4-(2-{2-[2-(2-azidoethoxy)ethoxy]ethoxy}ethoxy)benzaldehyde oxime 
• 1347750-79-1 2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethanethiol 
• 857284-78-7 S-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)ethanethioate 
• 31521-83-2 2-<2-(2-methoxyethoxy)ethoxy>ethylthiol 
• 352439-36-2 α-(2-azidoethyl)-ω-hydroxyhexa(oxyethylene) 
• 857892-34-3 23-azido-3,6,9,12,15,18,21-heptaoxatricosyl 4-methylbenzenesulfonate 
• 168640-86-6 3,4,5-Tris-[2-(2-{2-[2-(2-chloro-acetylamino)-ethoxy]-ethoxy}-ethoxy)-ethoxy]-benzoic acid methyl ester 
• 168640-84-4 3,4,5-Tris-(2-{2-[2-(2-azido-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid 
• 168640-85-5 3,4,5-Tris-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-benzoic acid methyl ester 

Relevant articles and documents

A lysosomal chloride ion-selective fluorescent probe for biological applications

Lysosomal pHs are maintained at low values by the cooperative action of a proton pump and a chloride channel to maintain electroneutrality. Owing to the biological significance of lysosomal chloride ions, measurements of their levels are of great importan

Synthesis and characterization of fluorinated conjugates of albumin

A small fluorocarbon dendron that contains nine chemically identical fluorine atoms was covalently conjugated to albumin via a flexible linker. Two versions were made, which differ by 10% in the linker length. Both versions display split 19F signal and much shorter 19F longitudinal relaxation time than their small molecule counterparts. 10% difference in the flexible linker length has negligible impact on the 19F signal.

Isorhamnetin biotin probe, synthesis method and application thereof

The invention relates to an isorhamnetin biotin probe, a synthesis method and application thereof, the probe takes isorhamnetin as a reaction group and biotin as an affinity tag, and has the structureshown as the formula in the specification, wherein X is

Pyrene-Based “Turn-Off” Probe with Broad Detection Range for Cu2+, Pb2+ and Hg2+ Ions

Detection of metals in different environments with high selectivity and specificity is one of the prerequisites of the fight against environmental pollution with these elements. Pyrenes are well suited for the fluorescence sensing in different media. The

Acetylcholin esterase degradation compound as well as preparation method and application thereof

The invention discloses an acetylcholin esterase degradation compound as well as a preparation method and application thereof. The acetylcholin esterase degradation compound is a compound shown as a general formula Wa or Wb. According to the invention, AChE ligand and CRBN ligand are connected by adopting a proper means, and a new compound is designed and obtained, so that the degradation of the AChE can be specifically enhanced, and the purpose of treating related diseases is achieved. The compound and the pharmaceutically acceptable salt thereof can be used for preparing medicines for treating diseases, disorders or symptoms beneficial to acetylcholin esterase degradation. The AChE degradation enhancing compound has a unique induced protein degradation mechanism, only a small amount of medicine is needed, the process is similar to a catalytic reaction, the medicine with the equal molar weight is not needed, and the use dosage of the medicine and toxic and side effects can be reducedby using difunctional small molecules.