857934-92-0Relevant academic research and scientific papers
MEDIUM- OR MACRO-CYCLIC BENZYL-SUBSTITUTED HETEROCYCLE DERIVATIVES AND THEIR USES AS OREXIN-2 RECEPTOR AGONISTS
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Paragraph 0842-0843, (2022/03/22)
The present disclosure relates to compounds of Formula (I') and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating orexin-2 receptor activity and may be used m the treatment of disorders in which orexin-2 receptor activity is implicated, such as narcolepsy, a hypersomnia disorder, a neurodegenerative disorder, a symptom of a rare genetic disorder, a mental health disorder, a metabolic syndrome, osteoporosis, cardiac failure, coma, or facilitating emergence from anaesthesia.
Design, generation, and synthetic application of borylzincate: Borylation of aryl halides and borylzincation of benzynes/terminal alkyne
Nagashima, Yuki,Takita, Ryo,Yoshida, Kengo,Hirano, Keiichi,Uchiyama, Masanobu
supporting information, p. 18730 - 18733 (2014/01/06)
Borylzincate was generated in situ from dialkylzinc, diboron, and metal alkoxide. Model DFT calculations showed that although the formation of borylzincate is kinetically favorable, it is thermodynamically unfavorable. Therefore, we designed a successive reaction sequence that would provide a compensating energy gain. This enabled Zn-catalyzed borylation of aryl halides and borylzincation of benzynes and terminal alkyne from diborons without the need for any cocatalyst.
Preparation and selective reactions of mixed bimetallic aromatic and heteroaromatic boron-magnesium reagents
Baron, Oliver,Knochel, Paul
, p. 3133 - 3135 (2007/10/03)
(Chemical Equation Presented) It's all in the mix: The magnesiation of iodoaryl and iodoheteroaryl boronic esters with iPrMgCl·LiCl leads to mixed bimetallic compounds, which react with a variety of electrophiles to provide highly functionalized boronic e
